Exploration of the Role of m(6) A RNA Methylation Regulators in Malignant Progression and Clinical Prognosis of Ovarian Cancer.
Exploration of the Role of m(6) A RNA Methylation Regulators in Malignant Progression and Clinical Prognosis of Ovarian Cancer.
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m6A RNA甲基化调节因子在卵巢癌恶性进展和临床预后中的作用探讨
DOI：
10.3389/fgene.2021.650554
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发表时间：
2021
影响因子：
3.7
通讯作者：
Yi P
中科院分区：
文献类型：
--
作者：
Wei Q;Yang D;Liu X;Zhao H;Yang Y;Xu J;Liu T;Yi P
卵巢癌是世界上最致命的妇科恶性肿瘤，它是必要的，以剖析关键的基因调控网络在卵巢癌。N6-甲基腺苷（m6 A）RNA甲基化作为最普遍的RNA修饰，由m6 A RNA甲基化调节剂协调，并且已经涉及各种癌症的恶性进展。在这项研究中，我们研究了卵巢癌中m6 A RNA甲基化调节因子的遗传格局和表达谱，发现几种m6 A RNA甲基化调节因子在卵巢癌中频繁扩增和上调。利用共识聚类分析，我们将卵巢癌样本分为四个具有不同m6 A甲基化模式的聚类，这些亚组中的患者显示出不同的临床结果。采用多变量考克斯比例风险模型筛选与卵巢癌预后相关的关键m6 A调节因子，并采用LASSO考克斯回归构建预测预后的基因标签。生存分析显示，风险基因标签可作为卵巢癌的独立预后标志。总之，m6 A RNA甲基化调节因子与卵巢癌的恶性进展相关，可能是卵巢癌预后预测的一个潜在指标。
Ovarian cancer is the most deadly gynecologic malignancy worldwide and it is warranted to dissect the critical gene regulatory network in ovarian cancer. N6-methyladenosine (m6A) RNA methylation, as the most prevalent RNA modification, is orchestrated by the m6A RNA methylation regulators and has been implicated in malignant progression of various cancers. In this study, we investigated the genetic landscape and expression profile of the m6A RNA methylation regulators in ovarian cancer and found that several m6A RNA methylation regulators were frequently amplified and up-regulated in ovarian cancer. Utilizing consensus cluster analysis, we stratified ovarian cancer samples into four clusters with distinct m6A methylation patterns and patients in these subgroups displayed the different clinical outcomes. Moreover, multivariate Cox proportional hazard model was used to screen the key m6A regulators associated with the prognosis of ovarian cancer and the last absolute shrinkage and selection operator (LASSO) Cox regression was used to construct the gene signature for prognosis prediction. The survival analysis exhibited the risk-gene signature could be used as independent prognostic markers for ovarian cancer. In conclusion, m6A RNA methylation regulators are associated with the malignant progression of ovarian cancer and could be a potential in prognostic prediction for ovarian cancer.
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影响因子：
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作者：
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作者：
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通讯作者：
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通讯作者：
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