CLINICAL AND AUTOANTIBODY CORRELATIONS IN ORIENTALS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
CLINICAL AND AUTOANTIBODY CORRELATIONS IN ORIENTALS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1136/ard.47.11.918
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发表时间：
1988-11-01
影响因子：
27.4
通讯作者：
TAN, EM
中科院分区：
文献类型：
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作者：
BOEY, ML;PEEBLES, CL;TAN, EM
对新加坡一家医疗单位94例系统性红斑狼疮(SLE)患者的血清样本进行了10种不同特异性的自身抗体分析。抗双链(DS)DNA(43%)、组蛋白(81%)、Sm(26%)、核核蛋白(NRNP)(32%)、SS-A(Ro)(63%)、SS-B(La)(12%)、SL/KI(9%)、核糖体RNP(RRNP)(16%)、p70/p80(5%)、增殖细胞核抗原(PCNA)(3%)。除抗SS-A(Ro)的患病率较高外，其他自身抗体均在西方国家报道的范围内，表明不同国家SLE自身抗体谱高度一致。有神经精神症状的患者比没有神经精神症状的患者显示出更高的抗体复数，4.22v2.77。抗-Sm抗体阳性的患者更易患活动性狼疮。在那些有肾脏表现的人中，没有增加患病率或特定类型的自身抗体。
Serum samples from 94 patients with systemic lupus erythematosus (SLE) from a medical unit in Singapore were analysed for autoantibodies of 10 different specificities. The prevalence of antibodies to the following antigens was as follows: double stranded (ds) DNA (43%), histone (81%), Sm (26%), nuclear ribonuclear protein (nRNP) (32%), SS-A(Ro) (63%), SS-B(La) (12%), SL/Ki (9%), ribosomal RNP (rRNP) (16%), p70/p80 (5%), proliferating cell nuclear antigen (PCNA) (3%). Except for a higher prevalence of anti-SS-A(Ro), other autoantibodies were within the range reported from Western countries, indicating a high uniformity of autoantibody profiles in SLE in different countries. Patients with neuropsychiatric manifestations showed a higher plurality of antibodies per patient than patients without neuropsychiatric symptoms, 4.22 v 2.77. Patients with anti-Sm were more likely to have active lupus disease. There was no increased prevalence or specific type of autoantibody in those with renal manifestations.