Voxel-based lesion-symptom mapping
Voxel-based lesion-symptom mapping
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DOI：
10.1038/nn1050
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发表时间：
2003-05-01
影响因子：
25
通讯作者：
Dronkers, NF
中科院分区：
文献类型：
--
作者：
Bates, E;Wilson, SM;Dronkers, NF
一个多世纪以来，病变-症状图谱研究已经对大脑和行为之间的关系产生了有价值的见解，但新的成像技术在检查功能网络方面已经超过了病变分析。在这里，我们使用了一种新的方法-基于体素的病变症状映射(VLSM)-来分析组织损伤和行为之间的关系，在逐个体素的基础上，就像在功能神经成像中一样。我们将VLSM应用于101名左脑受损失语症患者的语言流畅性和语言理解的测量：这些测量的VLSM图证实了预期的前部和后部区域之间的对比，它们也表明相互作用的区域促进了流畅性和听觉理解，这与现代脑成像的结果一致。
For more than a century, lesion–symptom mapping studies have yielded valuable insights into the relationships between brain and behavior, but newer imaging techniques have surpassed lesion analysis in examining functional networks. Here we used a new method—voxel-based lesion–symptom mapping (VLSM)—to analyze the relationship between tissue damage and behavior on a voxel-by-voxel basis, as in functional neuroimaging. We applied VLSM to measures of speech fluency and language comprehension in 101 left-hemisphere-damaged aphasic patients: the VLSM maps for these measures confirm the anticipated contrast between anterior and posterior areas, and they also indicate that interacting regions facilitate fluency and auditory comprehension, in agreement with findings from modern brain imaging.