The complex role of interleukin-10 in autoimmunity
The complex role of interleukin-10 in autoimmunity
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DOI：
10.1016/s0896-8411(03)00044-1
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发表时间：
2003-06-01
影响因子：
12.8
通讯作者：
Cottrez, F
中科院分区：
文献类型：
--
作者：
Groux, H;Cottrez, F
白细胞介素 - 10（IL - 10）是一种细胞因子，基于其下调辅助性T细胞1型反应的能力，即干扰素 - γ分泌以及单核细胞/巨噬细胞的活化，已在不同的临床试验中进行了测试。在不同的动物模型中也有证据表明，IL - 10可能有助于控制辅助性T细胞2介导的炎症过程。然而，IL - 10也表现出免疫刺激特性，尤其是对B细胞和活化的CD8（+）T细胞。这些看似不同的作用可能解释了在一些动物模型或临床试验中IL - 10治疗后明显缺乏活性或出现不良反应的现象。尽管如此，IL - 10诱导调节性CD4（+）T细胞亚群（Tr1）分化的能力以及IL - 10对调节性T细胞体内功能的重要性，倾向于支持将IL - 10视为控制免疫反应的关键细胞因子这一观点。在不同的体内模型中，这些细胞被证明可通过分泌IL - 10抑制辅助性T细胞1型和辅助性T细胞2型炎症反应。因此，这些Tr1细胞可用于特定的细胞疗法，以便将IL - 10精确地输送到炎症部位。（C）2003爱思唯尔科学有限公司。保留所有权利。
Interleukin- 10 (IL-10) is a cytokine that has been tested in different clinical trials based on its ability to down regulate T helper 1-type responses, namely IFN-gamma secretion and activation of monocytes/macrophages. There is also evidence in different animal models, that IL-10 could be useful in controlling Th2-mediated inflammatory processes. However, IL-10 also displays immunostimulatory properties especially on B cells and activated CD8(+) T cells. These seemingly divergent effects may explain the apparent lack of activity or adverse effects observed after IL-10 treatment in several animal models or clinical trials. Nevertheless, the ability of IL-10 to induce the differentiation of a subset of regulatory CD4(+) T cells (Tr1) and the importance of IL-10 for the in vivo function of regulatory T cells tends to support the view of IL-10 as a crucial cytokine in the control of immune responses. In different in vivo models, these cells were shown to inhibit Th1 and Th2-type inflammatory responses through the secretion of IL-10. These Tr1 cells may thus be used in specific cellular therapy in order to deliver IL-10 precisely at the site of inflammation. (C) 2003 Elsevier Science Ltd. All rights reserved.