Intrapartum tenofovir and emtricitabine reduces low-concentration drug resistance selected by single-dose nevirapine for perinatal HIV prevention.
Intrapartum tenofovir and emtricitabine reduces low-concentration drug resistance selected by single-dose nevirapine for perinatal HIV prevention.
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产时替诺福韦和恩曲他滨可降低单剂量奈韦拉平选择的低浓度耐药性，用于围产期 HIV 预防。
DOI：
10.1089/aid.2009.0088
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发表时间：
2009
影响因子：
1.5
通讯作者：
Stringer,JeffreySA
中科院分区：
文献类型：
--
作者：
Chi,BenjaminH;Ellis,GiovaninaM;Chintu,Namwinga;Cantrell,RonaldA;Sinkala,Moses;Aldrovandi,GraceM;Warrier,Ranjit;Mbewe,Felistas;Nakamura,Kyle;Stringer,ElizabethM;Frenkel,LisaM;Stringer,JeffreySA
A single dose of tenofovir/emtricitabine (TDF/FTC) during labor significantly reduces peripartum nevirapine-associated viral drug resistance when measured by consensus HIV sequencing. It is unknown whether this effect extends to HIV subpopulations of <25–50%. We conducted a randomized trial of single-dose TDF/FTC added to peripartum nevirapine to reduce drug resistance associated with nonnucleoside reverse transcriptase inhibitors (NNRTIs). To detect mutations for NNRTIs comprising ≥2% of the viral population, we used an oligonucleotide ligation assay (OLA) at codons 103, 106, 181, and 190 of HIV reverse transcriptase. To assess development of drug resistance mutations to our study intervention, OLA was also performed at codons 65 and 184. Among the 328 women included in the 2-week analysis, those receiving TDF/FTC were less likely to have NNRTI resistance by OLA (RR = 0.40, 95% CI = 0.21–0.77). A similar trend was observed among the 315 women included in the 6-week analysis (RR = 0.45, 95% CI = 0.31–0.66). Only two (1%) specimens had detectable K65R by OLA. Both were at 6 weeks postpartum; one was detected in the intervention arm and one in the control arm (p= 0.96). M184V was not detected. The ability of single-dose TDF/FTC to protect against peripartum NVP-induced NNRTI resistance extends to minority populations. This efficacy is achieved without significant selection of TDF- or FTC-resistant viruses.
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影响因子：
120.7
作者：
Stringer, Jeffrey S. A.;Zulu, Isaac;Sinkala, Moses
通讯作者：
Sinkala, Moses
影响因子：
3.8
作者：
Peuchant, Olivia;Thiebaut, Rodolphe;Masquelier, Bernard
通讯作者：
Masquelier, Bernard
影响因子：
6.4
作者：
Johnson, JA;Li, JF;Heneine, W
通讯作者：
Heneine, W
产时单剂量奈韦拉平加齐多夫定预防后，产后期间奈韦拉平的持续暴露，以预防 HIV-1 母婴传播
DOI：
10.1097/01.qai.0000149791.37205.b1
发表时间：
2005
期刊：
JAIDS Journal of Acquired Immune Deficiency Syndromes
影响因子：
--
作者：
T. Cressey;G. Jourdain;M. Lallemant;S. Kunkeaw;J. B. Jackson;P. Musoke;E. Capparelli;M. Mirochnick
通讯作者：
M. Mirochnick
影响因子：
9.4
作者：
FRENKEL, LM;WAGNER, LE;DEWHURST, S
通讯作者：
DEWHURST, S