Five-year incidence of age-related maculopathy lesions - The Blue Mountains Eye Study
Five-year incidence of age-related maculopathy lesions - The Blue Mountains Eye Study
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DOI：
10.1016/s0161-6420(02)01055-2
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发表时间：
2002-06-01
期刊：
影响因子：
13.7
通讯作者：
Smith, W
中科院分区：
文献类型：
--
作者：
Mitchell, P;Wang, JJ;Smith, W
目的：描述5年的发病率和进展的早期和晚期年龄相关性黄斑病变（ARM）lesions.Design：人口为基础的队列study.Participants：三千六百五十四noninstitutional居民，年龄49岁或以上，住在蓝山地区西部的悉尼，澳大利亚，参加了1992年至1994年期间的研究。5年后（1997-1999年）对该队列进行了重新检查。排除543名参与者死亡，自基线，2335（75%）的幸存者参加了5年的随访examinations.Methods：视网膜照片从这两个考试进行了分级使用威斯康星州ARM分级系统。照片的参与者与任何ARM病变在任何一个考试进行了重新分级详细使用修改的并排的方法开发的比弗坝Eye Study.Main Outcome Measures：发病率和进展的ARM病变的定义在一个类似的方式中使用的比弗坝Eye Study.Results：所有ARM病变的发病率显着增加与年龄。对于晚期ARM病变（地图状萎缩和新生血管性ARM），总体5年发生率为1.1%。基线时，60岁及以下、60 - 69岁、70 - 79岁和80岁及以上受试者的合并晚期ARM发生率分别为0.0%、0.6%、2.4%和5.4%。在排除基线时任一眼有早期或晚期ARM的受试者后，早期ARM的总体5年发生率为8.7%，包括相应年龄组的3.2%、7.4%、18.3%和14.8%。女性新生血管ARM的发病率是男性的两倍（P = 0.1）。结论：本研究记录了澳大利亚老年人群中ARM病变的发病率。与比弗坝眼部研究相比，我们人群中色素沉着过度的发生率略高，这可能是由于样本变异性，或者这可能反映了两个人群之间的真实的差异。我们的软玻璃疣发生率较低可能是由于我们没有将中度软玻璃疣纳入软玻璃疣的明显和不明显类别。眼科学2002;109：1092-1097（C）2002，美国眼科学会。
Purpose: To describe the 5-year incidence and progression of early and late age-related maculopathy (ARM) lesions.Design: Population-based cohort study.Participants: Three thousand six hundred fifty-four noninstitutionalized residents, aged 49 years or older, living in the Blue Mountains area west of Sydney, Australia, participated in the study during 1992 to 1994. The cohort was reexamined after 5 years (1997-1999). Excluding 543 participants who died since the baseline, 2335 (75%) survivors attended 5-year follow-up examinations.Methods: Retinal photographs from both examinations were graded using the Wisconsin ARM Grading System. Photographs of participants with any ARM lesions at either examination were regraded in detail using a modification of the side-by-side method developed for the Beaver Dam Eye Study.Main Outcome Measures: Incidence and progression of ARM lesions were defined in a similar manner to that used in the Beaver Dam Eye Study.Results: Incidence rates for all ARM lesions increased significantly with age. For late ARM lesions (geographic atrophy and neovascular ARM), the overall 5-year incidence was 1.1%. The combined late ARM incidence was 0.0%, 0.6%, 2.4%, and 5.4% for participants aged 60 years and younger, 60 to 69 years, 70 to 79 years, and 80 years and older at baseline, respectively. After excluding participants with either early or late ARM in either eye at baseline, the overall 5-year incidence of early ARM was 8.7%, including 3.2%, 7.4%, 18.3%, and 14.8% for the corresponding age groups. The incidence of neovascular ARM in women was double that for men (P = 0.1).Conclusions: This study has documented the incidence of ARM lesions in an older Australian population. The slightly higher incidence of hyperpigmentation found in our population compared with the Beaver Dam Eye Study may be due to sample variability, or this could reflect real differences between the two populations. Our lower incidence of soft drusen could have resulted from our noninclusion of intermediate soft drusen in the soft distinct and indistinct drusen categories. Ophthalmology 2002;109:1092-1097 (C) 2002 by the American Academy of Ophthalmology.