Self-regulatory depletion increases emotional reactivity in the amygdala.
Self-regulatory depletion increases emotional reactivity in the amygdala.
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DOI：
10.1093/scan/nss082
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发表时间：
2013-04
影响因子：
4.2
通讯作者：
D. Wagner;T. Heatherton
中科院分区：
文献类型：
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作者：
D. Wagner;T. Heatherton
当人们被要求进行连续的努力自我控制的行为时，自我调节的能力可能会受到损害，即使自我控制发生在不同的领域。在这里，我们使用功能神经成像来测试在认知领域从事努力抑制是否会导致情绪领域的假定功能障碍。48名参与者在两次会议中观看了功能性磁共振成像过程中情绪场景的图像，这两次会议被一项具有挑战性的注意力控制任务分开，这项任务需要努力抑制(耗竭组)或不需要努力抑制(控制组)。与对照组相比，精疲力竭的参与者表现出左侧杏仁核负向活动的增加，但没有表现出积极或中性的场景。此外，尽管对照组对所有场景类型(即习惯性)表现出杏仁核活动的减少，但与消耗前的基线相比，缺乏组的杏仁核活动增加；然而，这只在负面场景中显著。最后，在消极的场景处理过程中，精疲力竭的参与者表现出左侧杏仁核和腹内侧额前皮质之间的功能连接减少。这些发现表明，消耗自我调节资源会导致对情绪材料的夸大神经反应，这种反应似乎是针对负价刺激的，并进一步表明，未能招募参与情绪调节的自上而下的前额叶区域。
The ability to self-regulate can become impaired when people are required to engage in successive acts of effortful self-control, even when self-control occurs in different domains. Here, we used functional neuroimaging to test whether engaging in effortful inhibition in the cognitive domain would lead to putative dysfunction in the emotional domain. Forty-eight participants viewed images of emotional scenes during functional magnetic resonance imaging in two sessions that were separated by a challenging attention control task that required effortful inhibition (depletion group) or not (control group). Compared to the control group, depleted participants showed increased activity in the left amygdala to negative but not to positive or neutral scenes. Moreover, whereas the control group showed reduced amygdala activity to all scene types (i.e. habituation), the depletion group showed increased amygdala activity relative to their pre-depletion baseline; however this was only significant for negative scenes. Finally, depleted participants showed reduced functional connectivity between the left amygdala and ventromedial prefrontal cortex during negative scene processing. These findings demonstrate that consuming self-regulatory resources leads to an exaggerated neural response to emotional material that appears specific to negatively valenced stimuli and further suggests a failure to recruit top-down prefrontal regions involved in emotion regulation.