Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics: Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study
Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics: Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study
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DOI：
10.1111/ejh.13028
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发表时间：
2018-04-01
影响因子：
3.1
通讯作者：
Cooper, David L.
中科院分区：
文献类型：
--
作者：
Batt, Katharine;Boggio, Lisa;Cooper, David L.
目的评价P-FIQ研究各亚组在总体HRQOL、疼痛、功能和关节状况方面的差异。方法成年男性血友病患者填写疼痛病史和患者报告结果量表EQ-5D-5L、简明疼痛问卷v2简表(BPI)、国际体力活动问卷(IPAQ)和血友病活动清单(HAL)；可选地，评估关节状态(血友病联合健康评分v2.1[HJHS])。结果381名成年男性血友病患者入选，中位年龄34岁。在EQ-5D-5L指数、BPI疼痛严重程度/干预、HAL总分和HJHS上的较差分数通常与受过大学教育、失业、自我报告急性和慢性疼痛以及自我报告焦虑/抑郁有关。结论高教育程度、失业、自我报告有急性和慢性疼痛、自我报告有焦虑/抑郁的参与者的关节状况和HRQL测量持续较低。更好地了解这些因素与疾病结局的关系可能会改善患者的个体化管理。
IntroductionPain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics.ObjectiveTo evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups.MethodsAdult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics.ResultsA total of 381 adult males with hemophilia were enrolled, with median age of 34years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression.ConclusionsMeasures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.