Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring
Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring
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DOI：
10.1016/j.ajog.2010.06.042
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发表时间：
2010-11-01
影响因子：
9.8
通讯作者：
Aguila, Marcia B.
中科院分区：
文献类型：
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作者：
Gregorio, Bianca M.;Souza-Mello, Vanessa;Aguila, Marcia B.
目的：本研究旨在验证母鼠在妊娠关键期和/或哺乳期摄入高脂饲料易诱发成年C57 BL/6小鼠后代患非酒精性脂肪肝的假设，研究设计：雄性幼鼠分为5组：（1）SC，来自标准饲料喂养的母鼠;（2）G，来自妊娠期高脂饲料喂养的母鼠;（3）L，来自哺乳期（L）HF喂养的母鼠;（4）GL，来自妊娠期和哺乳期（GL）HF喂养的母鼠;和（5）GL/HF，来自GL期间HF喂养的母鼠，从断奶后到成年保持HF饮食。我们分析了体质量、血浆和肝脏结构。结果：G后代表现出胰岛素抵抗和较低的葡萄糖转运蛋白-2表达。肝脂肪变性存在于G、L、GL中，并且主要存在于GL/HF后代中。固醇调节元件结合蛋白-1C的表达在G，GL，GL/HF的后代。结论：编程HF的食物容易在成年后代的肝脏的肝脏不良重塑。
OBJECTIVE: This work aimed to verify the hypothesis that maternal intake of high-fat diet in critical periods of pregnancy and/or suckling period predisposes nonalcoholic fatty liver disease in adult C57BL/6 mice offspring.STUDY DESIGN: Male pups were divided into 5 groups: (1) SC, from standard chow-fed dams; (2) G, from high-fat chow (HF)-fed dams during the gestation (G) period; (3) L, from HF-fed dams during the lactation (L) period; (4) GL, from HF-fed dams during the gestation and lactation (GL) periods; and (5) GL/HF, from HF-fed dams during GL, maintaining an HF diet from postweaning to adulthood. We analyzed body mass, plasma blood, and liver structure.RESULTS: The G offspring showed insulin resistance and lower glucose transporter-2 expression. Hepatic steatosis was present in the G, L, GL, and mainly in GL/HF offspring. Sterol regulatory element-binding protein-1c expression was higher in G, GL, and GL/HF offspring.CONCLUSION: Programming by HF chow predisposes hepatic adverse remodeling in the liver of adult offspring.