Preeclampsia is Associated with lower Percentages of Regulatory T Cells in Maternal Blood
Preeclampsia is Associated with lower Percentages of Regulatory T Cells in Maternal Blood
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DOI：
10.1080/10641950802601237
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发表时间：
2009-01-01
影响因子：
1.5
通讯作者：
Erwich, Jan Jaap H. M.
中科院分区：
文献类型：
--
作者：
Prins, Jelmer R.;Boelens, Hendrik M.;Erwich, Jan Jaap H. M.
目的：免疫机制参与子痫前期的病理生理。在怀孕期间，调节性T （Treg）细胞增加，这在调节对免疫不同的胎儿的耐受性方面起重要作用。我们假设在子痫前期患者中Treg细胞的百分比降低。方法：采集26例健康孕妇和18例子痫前期患者外周血。流式细胞术检测Treg细胞。结果：妊娠合并子痫前期的妇女CD4(+)FOXP3(+) Treg细胞的百分比明显降低。结论：我们认为调节性T细胞的缺乏可能在子痫前期的病理生理中起作用。
Objective: Immunological mechanisms are involved in the pathophysiology of preeclampsia. During pregnancy there is an increase in regulatory T (Treg) cells, which has an important role in regulating tolerance to the immunologically distinct fetus. We hypothesised that percentages of Treg cells are decreased in preeclamptic patients. Methods: Peripheral blood was obtained from 26 healthy pregnant controls and 18 preeclamptic patients. Treg cells were measured using flow-cytometry. Results: Women with pregnancies complicated by preeclampsia had significantly lower percentages of CD4(+)FOXP3(+) Treg cells. Conclusion: We conclude that a deficiency of regulatory T cells may play a role in the pathophysiology of preeclampsia.