Functional Segregation and Development of Mouse Higher Visual Areas
Functional Segregation and Development of Mouse Higher Visual Areas
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DOI：
10.1523/jneurosci.0731-17.2017
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发表时间：
2017-09-27
影响因子：
5.3
通讯作者：
Ohki, Kenichi
中科院分区：
文献类型：
--
作者：
Murakami, Tomonari;Matsui, Teppei;Ohki, Kenichi
最近的研究表明，小鼠视皮层中的高级视觉区域在解剖学上被分为两个视流，很可能类似于灵长类动物的腹流和背流。然而，小鼠体内的HVAS的功能尚未确定。此外，HVAS在发育过程中何时发生功能分离尚不清楚。在这里，我们使用广域钙成像研究了HV AS的时空选择性及其发展。我们发现，解剖腹侧流中的外侧HV具有相似的时空选择性，而解剖背流中的前、内侧HV的时空选择性并不一致，这些区域在功能上被分成多个组。这种功能性分离在睁眼(EO)后10d出现，并达到成体样形态。这些结果表明，不仅腹侧和背侧视流的功能分离，而且在背侧视流中还存在多个亚流，提示视流的功能分离是在EO后逐渐发生的。
Recent studies suggest that higher visual areas (HVAs) in the mouse visual cortex are segregated anatomically into two visual streams, likely analogous to the ventral and dorsal streams in primates. However, HVAs in mice have yet to be characterized functionally. Moreover, it is unknown when the functional segregation of HVAs occurs during development. Here, we investigated spatiotemporal selectivity of HV As and their development using wide-field calcium imaging. We found that lateral HV As in the anatomical ventral stream shared similar spatiotemporal selectivity, whereas the spatiotemporal selectivity of anterior and medial HVAs in the anatomical dorsal stream was not uniform and these areas were segregated functionally into multiple groups. This functional segregation of HVAs developed and reached an adult-like pattern similar to 10 d after eye opening (EO). These results suggest, not only the functional segregation of ventral and dorsal streams, but also the presence of multiple substreams in the dorsal stream, and indicate that the functional segregation of visual streams occurs gradually after EO.