THE REGENERATION OF AORTIC ENDOTHELIUM
THE REGENERATION OF AORTIC ENDOTHELIUM
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DOI：
10.1002/path.1700750116
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发表时间：
1958-01-01
期刊：
影响因子：
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通讯作者：
FLOREY, HW
中科院分区：
文献类型：
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作者：
POOLE, JCF;SANDERS, AG;FLOREY, HW
从下腹主动脉去除内皮后，对兔子主动脉内皮的再生进行了实验研究。最初被剥除内皮的区域首先被血小板和白细胞覆盖，但没有形成大的血栓。内皮细胞再生并逐渐覆盖裸露表面的大部分。然而，即使7个月后，内皮仍然没有完全覆盖缺损。新的内皮细胞是通过先前存在的内皮细胞的有丝分裂形成的。尽管之前有相反的报道，但我们没有发现任何证据表明内皮是由任何其他组织形成的，也没有证据表明核分裂的模式有任何异常。再生内皮的边缘显示出许多巨细胞，类似于先前研究人员在人类和动物血管中描述的巨细胞。
Regeneration of aortic endothelium in the rabbit was studied experimentally after removal of the endothelium from the lower abdominal aorta. The area initially denuded of endothelium is at 1st covered with platelets and leucocytes, but no large thrombus develops. Endothelium regenerates and gradually covers the greater part of the bared surface. However, even after 7 months, endothelium had still not completely covered the defect. New endothelial cells are formed by mitotic division from pre-existing endothelial cells. Despite previous reports to the contrary, we find no evidence that endothelium is formed from any other tissue or that there is anything unusual about the mode of nuclear division. The edge of the regenerating endothelium shows many giant-cells which resemble those described by previous workers in human and animal vessels.