Acoustic resolution photoacoustic Doppler flowmetry for assessment of patient rectal cancer blood perfusion.
Acoustic resolution photoacoustic Doppler flowmetry for assessment of patient rectal cancer blood perfusion.
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DOI：
10.1117/1.jbo.29.s1.s11517
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发表时间：
2024-01
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
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光声多普勒血流仪提供定量的血液灌注信息，除了光声血管造影直肠癌的评估。我们的目标是开发和验证相关多普勒血流仪利用声学分辨率光声显微镜（AR-PAM）系统的血液灌注分析。为了提取血流灌注信息，我们实现了AR-PAM多普勒血流仪，包括信号滤波和调理，A线相关，和角度补偿。我们开发了流动体模和造影剂，以系统地研究在一系列体模研究中的血流测定的功效。将开发的相关多普勒血流仪应用于在体内AR-PAM期间收集的图像，用于治疗后直肠癌评估。在体模研究中验证了多普勒血流测量系统的线性和准确度。对接受放化疗治疗的直肠癌患者进行成像，证明了使用相关多普勒血流测定法评估治疗反应并将残留癌与无癌肿瘤床组织和正常直肠组织区分开来的可行性。一种新的相关性多普勒血流仪的开发和验证，通过系统的体模评价。其应用于体内患者的结果表明，它可能是一个有用的除了光声内窥镜治疗后直肠癌评估。
Photoacoustic Doppler flowmetry offers quantitative blood perfusion information in addition to photoacoustic vascular contrast for rectal cancer assessment. We aim to develop and validate a correlational Doppler flowmetry utilizing an acoustic resolution photoacoustic microscopy (AR-PAM) system for blood perfusion analysis. To extract blood perfusion information, we implemented AR-PAM Doppler flowmetry consisting of signal filtering and conditioning, A-line correlation, and angle compensation. We developed flow phantoms and contrast agent to systemically investigate the flowmetry’s efficacy in a series of phantom studies. The developed correlational Doppler flowmetry was applied to images collected during in vivo AR-PAM for post-treatment rectal cancer evaluation. The linearity and accuracy of the Doppler flow measurement system were validated in phantom studies. Imaging rectal cancer patients treated with chemoradiation demonstrated the feasibility of using correlational Doppler flowmetry to assess treatment response and distinguish residual cancer from cancer-free tumor bed tissue and normal rectal tissue. A new correlational Doppler flowmetry was developed and validated through systematic phantom evaluations. The results of its application to in vivo patients suggest it could be a useful addition to photoacoustic endoscopy for post-treatment rectal cancer assessment.