Cyclic variation of oxytocin in the blood of pituitary portal vessels of rats.
Cyclic variation of oxytocin in the blood of pituitary portal vessels of rats.
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DOI：
10.1159/000124024
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发表时间：
1984
影响因子：
4.1
通讯作者：
Dipak K. Sarkar;Daniel Gibbs
中科院分区：
文献类型：
--
作者：
Dipak K. Sarkar;Daniel Gibbs
在Althesin麻醉下，观察了雌性大鼠动情周期垂体门脉血中催产素（OT）的释放。在4天发情周期的每个下午，用Althesin麻醉动物，并收集垂体门静脉血样。在发情前期14.00和16.00小时之间收集的门静脉血浆中的OT浓度（1，079 +/- 185 pg/ml）显著高于研究的任何其他时间。发情期（198 +/- 29 pg/ml）、发情后期（283 +/- 55 pg/ml）和间情期（267 +/- 49 pg/ml）的平均OT浓度之间没有明显差异。垂体门脉血浆中OT浓度也高于颈外静脉血（低于41-67 pg/ml）。Althesin麻醉大鼠门静脉血浆OT与外周血浆催乳素的比较表明，在发情周期中这些激素的释放之间存在关联。
The release of oxytocin (OT) into pituitary portal blood during the estrous cycle was studied in female rats under Althesin anesthesia. On each afternoon of the 4-day estrous cycle, animals were anesthetized with Althesin, and pituitary portal blood samples were collected. The concentration of OT in portal plasma collected between 14.00 and 16.00 h of proestrus (1,079 +/- 185 pg/ml) was significantly higher than that at any other time studied. There were no appreciable differences between the mean OT concentration on the days of estrus (198 +/- 29 pg/ml), metestrus (283 +/- 55 pg/ml), and diestrus (267 +/- 49 pg/ml). The concentration of OT in pituitary portal plasma was also greater than that in blood withdrawn from the external jugular vein (less than 41-67 pg/ml). Comparison of the portal plasma OT with peripheral plasma prolactin in Althesin-anesthetized rats indicated an association between the release of these hormones during the estrous cycle.