Direct comparison of retinal structure and function in retinitis pigmentosa by coregistering microperimetry and optical coherence tomography
Direct comparison of retinal structure and function in retinitis pigmentosa by coregistering microperimetry and optical coherence tomography
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DOI：
10.1371/journal.pone.0226097
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发表时间：
2019-12-12
期刊：
影响因子：
3.7
通讯作者：
Ikeda, Yasuhiro
中科院分区：
文献类型：
--
作者：
Funatsu, Jun;Murakami, Yusuke;Ikeda, Yasuhiro
目的通过对比微视野检查（MP-3）图像和光学相干断层扫描（OCT）图像，探讨视网膜色素变性（RP）黄斑区视网膜结构与功能的关系。用MP-3和OCT检查患者黄斑部，在中心视网膜16 °同心圆上设置40个测试点，用MP-3测量视网膜敏感度，并将40个测试点按距中心凹的角度分为4个区（2 °、4 °、6 °和8 °）。分析视网膜敏感度与视网膜总厚度（total retinal thickness，TRT）、内界膜至视网膜色素上皮（retinal pigment epithelium，RPE）的距离以及视网膜外厚度（outer retinal thickness，ORT）的相关系数，结果TRT与视网膜敏感度呈中度相关，相关系数为2（中位rho = 0.59四分位距（IQR）[0.38-0.72]）、4度（rho = 0.59 [0.55-0.68]）和6度（rho = 0.60 [0.54-0.63]），TRT与8度（rho = 0.27 [0.19-0.48]）的视网膜敏感性呈弱至中度相关。ORT在2度（rho = 0.72 [0.60-0.81]）、4度（rho = 0.71 [0.75-0.67]）和6度（rho = 0.70 [0.54-0.74]）时表现出强相关性，在8度（rho = 0.34 [0.29-0.53]）时表现出弱至中度相关性。ORT与视网膜敏感性的相关性更强，而TRT（p = 0.018）。结论ORT，而不是TRT，在6度偏心度与视网膜敏感性强相关，这表明，测量ORT在这些领域将有助于评估黄斑的状态和进展RP。
PurposeTo evaluate the retinal structure-function relationships in the macula of retinitis pigmentosa (RP) patients by comparing microperimetry-3 (MP-3) images with co-registered optical coherence tomography (OCT) images.MethodsThirty patients with typical RP were recruited from our hospital. The maculae of patients were examined with MP-3 and OCT. The retinal sensitivity was measured by MP-3 at 40 testing points arranged concentrically in a 16 degrees diameter of the central retina, and we divided the 40 points into four zones according to degree from the fovea (2 degrees, 4 degrees, 6 degrees, and 8 degrees). We analyzed the correlation coefficients between the retinal sensitivity and the total retinal thickness (TRT), the length from the inner limiting membrane to the retinal pigment epithelium (RPE), and between the retinal sensitivity and the outer retinal thickness (ORT), the length from the outer plexiform layer to the RPE at each stimulus point.ResultsTRT showed moderate correlations with the retinal sensitivity at 2 degrees (median rho = 0.59 interquartile range (IQR) [0.38-0.72]), 4 degrees (rho = 0.59 [0.55-0.68]) and 6 degrees (rho = 0.60 [0.54-0.63]), and TRT was weakly-to-moderately related to the retinal sensitivity at 8 degrees (rho = 0.27 [0.19-0.48]). ORT exhibited strong correlations at 2 degrees (rho = 0.72 [0.60-0.81]), 4 degrees (rho = 0.71 [0.75-0.67]) and 6 degrees (rho = 0.70 [0.54-0.74]), and a weak-to-moderate correlations at 8 degrees (rho = 0.34 [0.29-0.53]). ORT was more strongly correlated with the retinal sensitivity compared to TRT (p = 0.018).ConclusionORT, rather than TRT, within 6 degrees eccentricity was strongly correlated with the retinal sensitivity, suggesting that measuring ORT in those areas will help evaluate the macular status and progression in RP.