Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects.
Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects.
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DOI：
10.1155/2015/680853
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发表时间：
2015
影响因子：
4.6
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Wang W;Xu D;Wang B;Yan S;Wang X;Yin Y;Wang X;Sun B;Sun X
痛风是一种常见的炎症性疾病，以急性关节炎和高尿酸血症为特征。一些流行病学研究表明痛风在致癌性中的重要作用。本研究的目的是通过对迄今发表的所有相关研究的荟萃分析来估计痛风与癌症风险之间的关系。从PubMed和Embase数据库建立到2014年7月1日，进行全面的文献检索，以确定符合条件的研究。通过计算具有95%置信区间（95% ci）的汇总相对风险（rr）来评估痛风与不同癌症风险之间的关系强度。所有分析均采用STATA 12.0软件进行。痛风患者患癌症的风险增加，尤其是泌尿系统癌症、消化系统癌症和肺癌。痛风与乳腺癌或脑癌风险之间没有明显的联系。敏感性分析没有实质性地改变汇总结果。痛风是癌症的危险因素，尤其是泌尿系统癌症、消化系统癌症和肺癌。汇总的数据进一步支持了痛风和癌变之间联系的假设。
Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published to date. A comprehensive literature search in PubMed and Embase databases from their inception up to July 1, 2014, was performed to identify eligible studies. The strength for relationship between gout and the risk of different cancers was evaluated by calculating pooled relative risks (RRs) with 95% confidence intervals (95% CIs). All analyses were carried out by STATA 12.0 software. Gout patients were at an increased risk of cancer, particularly urological cancers, digestive system cancers, and lung cancer. No such significant association between gout and the risk of breast or brain cancers was observed. Sensitivity analysis did not materially alter the pooled results. Gout is a risk factor of cancer, particularly that of urological cancers, digestive system cancers, and lung cancer. The pooled data further support the hypothesis of a link between gout and carcinogenesis.