Diagnostic and prognostic values of integrin α subfamily mRNA expression in colon adenocarcinoma
Diagnostic and prognostic values of integrin α subfamily mRNA expression in colon adenocarcinoma
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DOI：
10.3892/or.2019.7216
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发表时间：
2019-09-01
期刊：
影响因子：
4.2
通讯作者：
Gao, Feng
中科院分区：
文献类型：
--
作者：
Gong, Yi-Zhen;Ruan, Guo-Tian;Gao, Feng
整合素α（ITGA）亚家族基因在各种癌症中发挥重要作用。然而，ITGA基因在结肠腺癌（COAD）中的作用机制和应用价值仍不清楚。本研究从诊断和预后的角度探讨ITGA基因在COAD中的表达意义。COAD RNA测序数据集获自癌症基因组图谱。本研究通过生物信息学分析研究ITGA亚家族基因的生物学功能。应用逆转录-定量聚合酶链反应（RT-PCR）检测COAD肿瘤及癌旁正常组织中整合素α 8（ITGA 8）的表达。生物信息学分析表明，ITGA基因在细胞粘附和整合素介导的信号通路中明显富集，并且相互共表达。观察发现，绝大多数基因在肿瘤组织中的表达显著降低（P
The integrin alpha (ITGA) subfamily genes play a fundamental role in various cancers. However, the potential mechanism and application values of ITGA genes in colon adenocarcinoma (COAD) remain elusive. The present study investigated the significance of the expression of ITGA genes in COAD from the perspective of diagnosis and prognosis. A COAD RNA-sequencing dataset was obtained from The Cancer Genome Atlas. The present study investigated the biological function of the ITGA subfamily genes through bioinformatics analysis. Reverse transcription-quantitative polymerase chain reaction was applied to investigate the distribution of integrin alpha 8 (ITGA8) expression in COAD tumors and adjacent normal tissues. Bioinformatics analysis indicated that ITGA genes were noticeably enriched in cell adhesion and the integrin-mediated signaling pathway, and co-expressed with each other. It was also revealed through observation that the majority of gene expression was significantly low in tumor tissues (P