A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders
A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders
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DOI：
10.1016/j.ijsolstr.2008.01.024
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发表时间：
2008-05-15
影响因子：
3.6
通讯作者：
Hancock, B. C.
中科院分区：
文献类型：
--
作者：
Han, L. H.;Elliott, J. A.;Hancock, B. C.
本文提出了一种改进的密度相关的Drucker-Prager Cap（DPC）模型来模拟药物粉末的压制行为。特别是，提出了一个非线性弹性定律来描述所观察到的非线性卸载行为压实。为了提取修改后的DPC模型的材料参数，使用一种新的实验校准程序，基于单轴单端压实试验，使用仪器化的圆柱形模具。通过编写用户子程序在ABAQUS中实现了该模型，并详细介绍了微晶纤维素（MCC）Avicel PH 101粉末的标定过程。利用标定后的参数对两种典型的片剂进行了生产过程模拟：平面片和单曲率或双曲率凹面片。所建立的模型不仅可以描述压缩和减压阶段，而且可以描述喷射阶段。该模型通过比较有限元模拟与实验加载-卸载曲线在制造8和11 mm的圆片与平面（FF），单半径凹（SRC）和双半径凹（DRC）的轮廓。并利用压片过程中的密度分布和应力分布，分析和解释了片剂的破坏机理。结果表明，该模型能够定量地再现药物粉末的压制行为，并可用于获得药物粉末在压制、减压和顶出过程中的应力和密度分布。(c)2008爱思唯尔有限公司保留所有权利。
In this paper, we present a modified density-dependent Drucker-Prager Cap (DPC) model to simulate the compaction behaviour of pharmaceutical powders. In particular, a nonlinear elasticity law is proposed to describe the observed nonlinear unloading behaviour following compaction. To extract the material parameters for the modified DPC model, a novel experimental calibration procedure is used, based on uniaxial single-ended compaction tests using an instrumented cylindrical die. The model is implemented in ABAQUS by writing a user subroutine, and a calibration process on microcrystalline cellulose (MCC) Avicel PH101 powders is detailed. The calibrated parameters are used for the manufacturing process simulation of two kinds of typical pharmaceutical tablets: the flat-face tablet and the concave tablet with single or double radius curvatures. The model developed can describe not only the compression and decompression phases, but also the ejection phase. The model is validated by comparing finite element simulations with experimental loading-unloading curves during the manufacture of 8 and 11 mm round tablets with flat-face (FF), single radius concave (SRC) and double radius concave (DRC) profiles. Moreover, the density and stress distributions during tabletting are used to analyse and explain the failure mechanism of tablets. The results show that the proposed model can quantitatively reproduce the compaction behaviour of pharmaceutical powders and can be used to obtain the stress and density distributions during compression, decompression and ejection. (c) 2008 Elsevier Ltd. All rights reserved.