Induction and extinction of mammary cancer. A striking effect of hydrocarbons permits analysis of mechanisms of causes and cure of breast cancer.
Induction and extinction of mammary cancer. A striking effect of hydrocarbons permits analysis of mechanisms of causes and cure of breast cancer.
复制标题
乳腺癌的诱发和消灭。
作者：
C. Huggins;N. Yang
本文介绍了乳腺癌的诱导和抑制在白化病大鼠的研究进行，以允许癌症的原因和灭绝的机制的分析2癌症研究的中心问题。单次喂食20 mg溶于芝麻油的712-二甲基苯并蒽（712-DMBA），在所有700多只健康雌性Sprague-Dawley品系大鼠中发生乳腺癌。芳香烃诱发的乳腺癌细胞学形态相似，均为乳头状腺癌。实验还表明，虽然712-DMBA和2-氨基菲是强致癌物，但苯并（a）蒽和菲不会诱发乳腺癌。甲基和羊水基团似乎将原本不活跃的母体分子物种转化为强大的致癌物。3个因素似乎决定了多环芳烃的乳腺致癌性：1）电子转移，2）几何因素和3）分子厚度。乳腺癌的消退是由两种类型的内分泌状态的改变引起的，一种是对癌症的生命和生长至关重要的激素的撤回，通常通过给予适当的激素进行卵巢切除术。在一项实验中，对先前通过给予712-DMBA诱发乳腺癌的雌性大鼠给予20 mcg雌二醇-17和4 mg孕酮，持续30天。在一组100只老鼠中，52只在尸检时没有癌症，而它们的对照同伴死于癌症。在更严格的条件下，用患大乳腺癌的大鼠重复了这个实验;结果同样成功。
This article describes the induction the induction and suppression of breast cancer in albino rats; the study was conducted to permit the analysis of the mechanisms of the causes and extinction of cancer 2 of the central problems in cancer research. A single feeding of 20 mg of 712 dimethylbenz(a)anthracene (712-DMBA) dissolved in sesame oil developed mammary cancer in all of over 700 healthy female rats of the Sprague-Dawley strain. The mammary cancer evoked by the aromatic hydrocarbons were all rather similar in cytologic appearance and all had the cellular pattern of papillary adenocarcinoma. Experiments also showed that while 712-DMBA and 2-aminophenanthrene were strong carcinogens benz(a)anthracene and phenanthrene did not evoke mammary cancer. It appears that the methyl and amnio groups convert the otherwise inactive parent molecular species to powerful carcinogens. 3 factors seem to determine mammary carcinogenicity in polynuclear aromatic hydrocarbons: 1) the electron transfer 2) the geometric factor and 3) the molecular thickness. Regression of mammary cancer has been induced by 2 types of alteration of the endocrine status the withdrawal of the hormones essential for the life and growth of the cancer usually done through ovariectomy on the administration of appropriate hormones. In an experiment female rats previously induced with mammary cancer through administration of 712-DMBA were given for 30 days 20 mcg of estradiol-17 and 4 mg of progesterone. In a group of 100 rats treated this way 52 were free from cancer at necropsy whereas their control companions succumbed to cancer. This experiment was repeated under more rigorous conditions with rats with large mammary cancers; the results were equally successful.