Selective suppression of hippocampal ripples impairs spatial memory
Selective suppression of hippocampal ripples impairs spatial memory
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DOI：
10.1038/nn.2384
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发表时间：
2009-10-01
影响因子：
25
通讯作者：
Zugaro, Michael B.
中科院分区：
文献类型：
--
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
在海马-内嗅皮层中的锐波-波纹（SPW-R）复合体被认为对于将不稳定记忆从海马转移到新皮层进行长期存储是重要的。我们发现，选择性消除SPW-Rs在训练后巩固期导致性能受损的大鼠训练依赖于校园的空间记忆任务。我们的结果为海马SPW-R在记忆巩固中的突出作用提供了证据。
Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.