Relationship between insulin resistance and partially oxidized LDL particles in healthy, nondiabetic volunteers
Relationship between insulin resistance and partially oxidized LDL particles in healthy, nondiabetic volunteers
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DOI：
10.1161/01.atv.18.5.762
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发表时间：
1998-05-01
影响因子：
8.7
通讯作者：
Reaven, GM
中科院分区：
文献类型：
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作者：
Carantoni, M;Abbasi, F;Reaven, GM
这项研究在 36 名健康志愿者中进行，旨在确定部分氧化低密度脂蛋白 (poxLDL) 血浆浓度、血浆葡萄糖和胰岛素对口服葡萄糖的反应，以及输注生长抑素、胰岛素和葡萄糖 180 分钟后稳态血浆葡萄糖 (SSPG) 浓度之间的关系。 poxLDL的浓度是通过测定在存在或不存在丙氨酸的情况下体外LDL氧化过程中形成的共轭二烯的量来估计的。在这些条件下，丙氨酸的体外抗氧化作用越大，血浆中存在的poxLDL的量越低。结果表明，血浆poxLDL浓度与血浆葡萄糖显着相关（r=.53，P
This study was performed in 36 healthy volunteers to define the relationship between plasma concentrations of partially oxidized low density lipoprotein (poxLDL), plasma glucose and insulin responses to oral glucose, and steady-state plasma glucose (SSPG) concentrations after a 180-minute infusion of somatostatin, insulin, and glucose. The concentration of poxLDL was estimated by determining the amount of conjugated dienes formed during in vitro LDL oxidation in the presence or absence of alanine, Under these conditions, the greater the in vitro antioxidant effect of alanine, the lower the amount of poxLDL that was present in plasma. The results demonstrated that plasma poxLDL concentration was significantly correlated with plasma glucose (r=.53, P