Oral manifestations and dental status in paediatric HIV infection.
Oral manifestations and dental status in paediatric HIV infection.
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DOI：
10.1046/j.1365-263x.2000.00170.x
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发表时间：
2000-03-01
影响因子：
3.8
通讯作者：
Greenspan, J S
中科院分区：
文献类型：
--
作者：
Ramos-Gomez, F J;Petru, A;Greenspan, J S
目的：描述围产期HIV感染儿童人群中HIV感染口腔表现的发生率和患病率。设计：对围产期HIV感染儿童队列进行回顾和前瞻性研究。集合：社区医院和社区儿科诊所。样本和方法：符合条件的40名围产期HIV感染儿童，中位年龄12个月。每个儿童每季度检查一次口腔症状、牙萌出情况，27名儿童进行口腔表现、龋齿和牙周状况检查。结果：出生后6个月内假膜性念珠菌病的发生率为43%(95%可信区间，27-58%)。口腔念珠菌病(定义为伪膜性或红斑性)与低的CD4计数和斑块的发生呈正相关。在调整年龄因素后，研究人员还发现，在儿童HIV感染中，低CD4值儿童的牙齿比高CD4值儿童少。结论：口腔表现在儿童HIV感染中很常见，可能是HIV疾病进展的预测因素。对感染艾滋病毒的儿童的初级保健应包括定期口腔检查，以监测他们的艾滋病毒疾病进展情况，并减轻与口腔机会性感染有关的症状。
OBJECTIVE: To describe the incidence and prevalence of oral manifestations of HIV infection in a population of perinatally infected children.DESIGN: Retrospective and prospective study of a cohort of perinatally HIV-infected children.SETTING: Community hospital and community-based paediatric clinic.SAMPLE AND METHODS: Forty perinatally HIV-infected children with a median age of 12 months were eligible and selected for the study, which included a medical chart review from birth and prospective follow-up. Each child was examined quarterly for oral manifestations, tooth eruption, and for 27 children, caries and periodontal status.RESULTS: The incidence of pseudomembranous candidiasis was 43% (95% CI, 27-58%) within 6 months of birth. Oral candidiasis (defined as pseudomembranous or erythematous) was positively associated with low CD4 counts and the occurrence of plaque. Children with low CD4 counts were also found to have fewer teeth than children with high CD4 counts, after adjusting for age.CONCLUSIONS: Oral manifestations are common in paediatric HIV infection and are possible predictors of HIV disease progression. Primary care of HIV-infected children should include periodic oral examinations to monitor their HIV disease progression and to alleviate symptoms associated with oral opportunistic infections.