Suppression of IgE antibody production in SJL mice. II. Expression of Ly-1 antigen on helper and nonspecific suppressor T cells.
Suppression of IgE antibody production in SJL mice. II. Expression of Ly-1 antigen on helper and nonspecific suppressor T cells.
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SJL 小鼠 IgE 抗体产生的抑制。
DOI：
10.4049/jimmunol.118.2.485
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发表时间：
1977
影响因子：
4.4
通讯作者：
Z. Óváry
中科院分区：
文献类型：
--
作者：
N. Watanabe;S. Kojima;F. Shen;Z. Óváry
在适当的免疫结合照射条件下，SJL/J 小鼠表现出高且持久的抗 DNP IgE 抗体反应。从正常未经处理的 SJL 小鼠转移的脾细胞抑制了这种反应。消除 Ly-1+ 细胞（但不消除 Ly-2+ 细胞）会消除脾细胞抑制 IgE 反应的能力。因此，在目前鉴定的三个T细胞Ly亚类Ly-1、Ly-2,3和Ly-1,2,3中，抑制辐射免疫的SJL小鼠的IgE反应的正常SJL脾细胞属于Ly-1组。目前尚不清楚 Ly-1 细胞是直接抑制 IgE 反应，还是通过帮助受体中的另一个细胞来抑制 IgE 反应。 IgE 和可能的 IgG1 抗体反应的载体特异性辅助细胞活性也属于 SJL 菌株中的 Ly-1 亚类。
Under appropriate conditions of immunization combined with irradiation, SJL/J mice show a high and persistent anti-DNP IgE antibody response. Spleen cells transferred from normal untreated SJL mice suppress this response. Elimination of Ly-1+ cells, but not of Ly-2+ cells, abolished the capacity of spleen cells to suppress the IgE response. Thus of the three T cell Ly subclasses presently identified, Ly-1, Ly-2,3, and Ly-1,2,3, the normal SJL spleen cell which suppresses the IgE response of irradiated-immunized SJL mice belongs to the Ly-1 set. It is not known whether this Ly-1 cell suppresses the IgE response directly or by helping another cell in the recipient. The carrier-specific helper cell activity for IgE and probably IgG1 antibody response belongs to Ly-1 subclass in the SJL strain also.