Histopathology of nonalcoholic fatty liver disease
Histopathology of nonalcoholic fatty liver disease
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DOI：
10.3748/wjg.v16.i42.5286
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发表时间：
2010-11-14
影响因子：
4.3
通讯作者：
Tiniakos, Dina G.
中科院分区：
文献类型：
--
作者：
Brunt, Elizabeth M.;Tiniakos, Dina G.
肝活检的组织学分析仍然是衡量非酒精性脂肪性肝病（NAFLD）肝损伤存在和程度的其他评估方法的标准。组织学评估仍然是区分脂肪变性和晚期NAFLD（即非酒精性脂肪性肝炎（NASH）和纤维化）的唯一方法。NAFLD的病变包括脂肪变性、小叶和门静脉炎症、肝细胞损伤（球囊和细胞凋亡）和纤维化。然而，这些病变的模式与病变本身一样有区别。成人和儿童因NAFLD引起的肝损伤可能具有不同的组织学模式。在这篇综述中，肝活检的基本原理，以及组织病理学病变，显微镜下观察到的损伤模式，以及NAFLD和NASH的鉴别诊断进行了讨论。(C) 2010年白石登。版权所有。
Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease (NAFLD) are measured. Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD, i.e. nonalcoholic steatohepatitis (NASH) and fibrosis. Included in the lesions of NAFLD are steatosis, lobular and portal inflammation, hepatocyte injury in the forms of ballooning and apoptosis, and fibrosis. However, patterns of these lesions are as distinguishing as the lesions themselves. Liver injury in adults and children due to NAFLD may have different histological patterns. In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed. (C) 2010 Baishideng. All rights reserved.