Indium-111 T101 monoclonal antibody is superior to iodine-131 T101 in imaging of cutaneous T-cell lymphoma.
Indium-111 T101 monoclonal antibody is superior to iodine-131 T101 in imaging of cutaneous T-cell lymphoma.
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Indium-111 T101 单克隆抗体在皮肤 T 细胞淋巴瘤的成像方面优于 iodine-131 T101。
DOI：
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发表时间：
1987
影响因子：
9.3
通讯作者：
M. Horowitz
中科院分区：
文献类型：
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作者：
J. Carrasquillo;J. Mulshine;P. Bunn;J. Reynolds;K. Foon;R. Schroff;P. Perentesis;R. Steis;A. Keenan;M. Horowitz
我们已经报道[111In]T101在淋巴结和皮肤（红皮病和肿瘤）部位的皮肤t细胞淋巴瘤（CTCL）检测中非常有效。该研究比较了[131I]T101（1至7.1 mg, 2 mCi）在4例CTCL患者中的生物分布；其中2例患者还接受了[111In]T101 （1mg, 5mci）治疗。[131I]T101从全身、脾脏、肝脏和骨髓中迅速清除，有证据表明T101中131I示踪剂丢失。4例患者中有3例淋巴结吸收极少，皮肤病变处没有定位。这与[111In]T101形成对比，T101在这些器官中有较长时间的活性保留，在皮肤肿瘤、红皮病和淋巴结中有良好的吸收。该研究表明[131I]T101对CTCL患者的成像不是最理想的，并表明同位素或标记方法可以显著改变给定单克隆抗体的表观生物分布和肿瘤靶向性。
We have reported that [111In]T101 is highly effective in the detection of cutaneous T-cell lymphoma (CTCL) in nodal and cutaneous (erythroderma and tumor) sites. This study compares the biodistribution of [131I]T101 (1 to 7.1 mg, 2 mCi) in four patients with CTCL; two of these patients also received [111In]T101 (1 mg, 5 mCi). There was rapid clearance of [131I]T101 from whole-body, spleen, liver, and bone marrow, with evidence of loss of 131I tracer from the T101. Lymph node uptake was minimal in three of four patients, and there was no localization in skin lesions. This contrasted with [111In]T101 where there was prolonged retention of activity in these organs and excellent uptake in skin tumors, erythroderma, and lymph nodes. The study showed that [131I]T101 was suboptimal for imaging CTCL patients and demonstrates that the isotope or labeling method can dramatically alter the apparent biodistribution and tumor targeting of a given monoclonal antibody.