RENAL BICARBONATE REABSORPTION IN THE RAT .2. DISTAL TUBULE LOAD DEPENDENCE AND EFFECT OF HYPOKALEMIA
RENAL BICARBONATE REABSORPTION IN THE RAT .2. DISTAL TUBULE LOAD DEPENDENCE AND EFFECT OF HYPOKALEMIA
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DOI：
10.1172/jci113087
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发表时间：
1987-08-01
影响因子：
15.9
通讯作者：
MALNIC, G
中科院分区：
文献类型：
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作者：
CAPASSO, G;JAEGER, P;MALNIC, G
我们研究了两组大鼠急性加载碳酸氢盐对照大鼠的标准饮食和大鼠保持在无钾饮食3周。与对照组相比，钾缺乏大鼠减少了碳酸氢盐的排泄分数，尽管他们的过滤碳酸氢盐负荷升高。钾耗竭大鼠远端重吸收增加。在存在几乎相同的早期远端碳酸氢盐负荷（481 .对照组为40 pmol/min，对照组为444 . ±. 50 pmol/min），远端碳酸氢盐重吸收在K耗竭中显著增强（247 . ±. 17 pmol/min）与对照组（179 . ±. 19pmol/min）。这些值是显着不同的彼此，都是几倍高于碳酸氢盐重吸收在空载条件下。总之，（a）远端碳酸氢盐重吸收是负荷依赖性的，（B）远端碳酸氢盐重吸收在钾耗竭中受到刺激。
We studied two groups of rats acutely loaded with bicarbonate control rats on a standard diet and rats kept on a K-free diet for 3 wk. Compared with controls, K-depleted rats had reduced fractional excretion of bicarbonate despite their elevated filtered bicarbonate load. Distal bicarbonate reabsorption increased in K-depleted rats. In the presence of almost identical early distal bicarbonate loads (481 .+-. 40 pmol/min in controls and 444 .+-. 50 pmol/min in K depletion), distal bicarbonate reabsorption was significantly enhanced in K depletion (247 .+-. 17 pmol/min) as compared with controls (179 .+-. 19 pmol/min). These values are significantly different from each other, and both are severalfold higher than bicarbonate reabsorption in nonloaded conditions. In conclusion, (a) distal bicarbonate reabsorption is load dependent, and (b) distal bicarbonate reabsorption is stimulated in K depletion.