Non-syndromic cleft lip and/or cleft palate: Epidemiology and risk factors in Lubumbashi (DR Congo), a case-control study
Non-syndromic cleft lip and/or cleft palate: Epidemiology and risk factors in Lubumbashi (DR Congo), a case-control study
复制标题
DOI：
10.1016/j.jcms.2018.05.006
复制
发表时间：
2018-07-01
影响因子：
3.1
通讯作者：
Reychler, Herve
中科院分区：
文献类型：
--
作者：
Mbuyi-musanzayi, Sebastien;Kayembe, Tony J.;Reychler, Herve
目的：了解卢本巴希地区非综合征性唇腭裂（NSCLP）的发病情况及危险因素。方法：2012年2月- 2015年12月在卢本巴希卫生区开展病例对照研究。对产科病房所有唇裂/腭裂新生儿（CL +/- P）进行全面抽样调查。从总共172例病例中，招募了162例无综合征病例。每个病例选择一名临床正常的新生儿作为对照。结果：NSCLP的发生率为1/1258（0.8/1000）。我们发现唇腭裂（CLP）家族史（x(2)家族史= 11.5,p = 0.0007）、母亲酒精摄入量（OR = 19.3, 95% CI: 1.9-197.1）、父亲在围孕期和妊娠前三个月饮酒（OR = 18.7, 95% CI: 3.9-89.2）、母亲教育程度低于高中（OR = 9.5, 95% CI: 2.0-44.7）、怀孕期间粘土（Pemba）摄入量(OR = 38.3, 95% CI：9.3-157.0)，晚上使用杀虫剂（OR = 130.3, 95% CI: 13.2-1286.9），室内用木炭烹饪（Makala） （OR = 6.5, 95% CI: 1.22-34.5），以及经常食用被认为受到重金属污染的Kapolowe鱼（OR = 29.5, 95% CI: 7.4-116.7）。结论：在中非地区发现了诱发唇裂的几种环境危险因素。(C) 2018年欧洲颅颌面外科协会。Elsevier Ltd.出版。版权所有。
Purpose: To determine the incidence and risk factors of occurrence of non-syndromic cleft lip and/or cleft palate (NSCLP) in Lubumbashi.Method: A case-control study was conducted in the health district of Lubumbashi from February 2012 to December 2015. An exhaustive sampling, collecting all newborns with cleft lip and/or cleft palate (CL +/- P) in maternity wards was conducted. From a total of 172 cases, 162 non-syndromic cases were recruited. For each case, one clinically normal newborn control was selected.Results: NSCLP had an incidence of 1/1258 live births (0.8/1000). We found significant associations with a family history of cleft lip and palate (CLP) (x(2)family history = 11.5, p = 0.0007), maternal alcohol intake (OR = 19.3, 95% CI: 1.9-197.1), paternal alcohol during the periconceptional period and the first trimester of pregnancy (OR = 18.7, 95% CI: 3.9-89.2), maternal educational level lower than high school (OR = 9.5, 95% CI: 2.0-44.7), clay (Pemba) consumption during pregnancy (OR = 38.3, 95% CI: 9.3-157.0), the use of insecticides in the evening (OR = 130.3, 95% CI: 13.2-1286.9), indoor cooking with charcoal (Makala) (OR = 6.5, 95% CI: 1.22-34.5), and regular consumption of Kapolowe fish, supposedly contaminated with heavy metals (OR = 29.5, 95% CI: 7.4-116.7).Conclusion: Several environmental risk factors highly prevalent in Central Africa for facial clefting were found. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.