Platelet adhesive resistance of segmented polyurethane film surface-grafted with vinyl benzyl sulfo monomer of ammonium zwitterions.
Platelet adhesive resistance of segmented polyurethane film surface-grafted with vinyl benzyl sulfo monomer of ammonium zwitterions.
复制标题
DOI：
10.1016/s0142-9612(03)00365-x
复制
发表时间：
2003-10
期刊：
影响因子：
14
通讯作者：
Jun Zhang;Jiang Yuan;Youling Yuan;X. Zang;Jian Shen;Sicong Lin
中科院分区：
文献类型：
--
作者：
Jun Zhang;Jiang Yuan;Youling Yuan;X. Zang;Jian Shen;Sicong Lin
研究了粘附在接枝有 N,N-二甲基-N-(对乙烯基苯基)-N-(3-磺丙基)铵 (DMVSA) 的分段聚醚聚氨酯 (SPEU) 膜上的人血浆血小板。 SPEU 薄膜经过氧硫酸钾 (KPS) 羟基化，然后使用硝酸高铈铵 (CAN) 作为引发剂接枝 DMVSA。通过ATR-FTIR测定羟基化SPEU/CAN的混合时间和单体浓度对接枝聚合产率的影响。通过 ATR-FTIR 和 ESCA 对接枝膜的表面分析证实 DMVSA 成功接枝到 SPEU 膜表面。通过水接触角测量表明，接枝膜具有相对亲水的表面。以原始SPEU膜和羟基化SPEU膜为对照，通过富血小板血浆粘附研究和扫描电镜初步评估了移植膜改善的血液相容性。结果表明，接枝DMVSA的嵌段聚氨酯薄膜上的血小板附着大大减少。这种接枝磺铵两性离子单体的新型生物材料可能具有生物医学应用的潜力。
Platelet from human plasma adhered on the segmented poly(ether urethane) (SPEU) film grafted with N,N-dimethyl-N-(p-vinylbenyl)-N-(3-sulfopropyl) ammonium (DMVSA) was studied. SPEU films were hydroxylated by potassium peroxosulfate (KPS) and then grafted with DMVSA using ceric ammonium nitrate (CAN) as initiator. The mixing time of hydroxylated SPEU/CAN and the monomer concentration effect on graft polymerization yield were determined by ATR-FTIR. Surface analysis of the grafted films by ATR-FTIR and ESCA confirmed that DMVSA was successfully grafted onto the SPEU film surface. The grafted film possessed a relatively hydrophilic surface, as revealed by water contact angle measurement. The improved blood compatibility of the grafted films was preliminarily evaluated by a platelet-rich plasma adhesion study and scanning electron microscopy, using original SPEU and hydroxylated SPEU films as the controls. The results showed that platelet attachment was decreased greatly on the segmented polyurethane films grafted with DMVSA. This kind of new biomaterials grafted with sulfo ammonium zwitterionic monomers might have potential for biomedical applications.