Role of mechanosensitive channels/receptors in atherosclerosis.
Role of mechanosensitive channels/receptors in atherosclerosis.
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机械敏感通道/受体在动脉粥样硬化中的作用。
DOI：
10.1152/ajpcell.00396.2021
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Rahaman,ShaikO
中科院分区：
文献类型：
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作者：
Mukherjee,Pritha;Rahaman,SunehaG;Goswami,Rishov;Dutta,Bidisha;Mahanty,Manisha;Rahaman,ShaikO
机械力是关键的物理线索，可以影响调节细胞发育、组织维持和功能的许多细胞过程。机械力的贡献在血管系统中尤其重要，在血管系统中，它是胚胎发生和维持血管细胞（包括主动脉内皮细胞、驻留巨噬细胞和平滑肌细胞）生理功能所必需的。新出现的证据也已经确定了这些机械线索在血管系统的病理状况中的作用，例如动脉粥样硬化和相关疾病如高血压。在不同的机械换能器中，机械敏感离子通道/受体由于其参与许多生理和病理状况而日益突出。然而，只有少数潜在的机械感觉离子通道/受体已被证明参与动脉粥样硬化，其在疾病发展和进展中的确切作用仍然知之甚少。在这里，我们提供了一个全面的帐户，最近的研究调查的作用，机械敏感离子通道/受体在动脉粥样硬化。我们讨论了不同类型的机械敏感蛋白及其在炎症、内皮功能障碍、巨噬细胞泡沫细胞形成和病变发展中的特定作用，这些对动脉粥样硬化的发展和进展至关重要。本文讨论的研究结果将有助于了解血管疾病，特别是动脉粥样硬化的机械生物学现状，这对于开发这种疾病的创新和靶向治疗方法可能很重要。
Mechanical forces are critical physical cues that can affect numerous cellular processes regulating the development, tissue maintenance, and functionality of cells. The contribution of mechanical forces is especially crucial in the vascular system where it is required for embryogenesis and for maintenance of physiological function in vascular cells including aortic endothelial cells, resident macrophages, and smooth muscle cells. Emerging evidence has also identified a role of these mechanical cues in pathological conditions of the vascular system such as atherosclerosis and associated diseases like hypertension. Of the different mechanotransducers, mechanosensitive ion channels/receptors are gaining prominence due to their involvement in numerous physiological and pathological conditions. However, only a handful of potential mechanosensory ion channels/receptors have been shown to be involved in atherosclerosis, and their precise role in disease development and progression remains poorly understood. Here, we provide a comprehensive account of recent studies investigating the role of mechanosensitive ion channels/receptors in atherosclerosis. We discuss the different groups of mechanosensitive proteins and their specific roles in inflammation, endothelial dysfunction, macrophage foam cell formation, and lesion development, which are crucial for the development and progression of atherosclerosis. Results of the studies discussed here will help in developing an understanding of the current state of mechanobiology in vascular diseases, specifically in atherosclerosis, which may be important for the development of innovative and targeted therapeutics for this disease.