Impact of adherence to antiretroviral therapy in HIV-1-infected patients at a university public service in Brazil
Impact of adherence to antiretroviral therapy in HIV-1-infected patients at a university public service in Brazil
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DOI：
10.1089/108729101753287685
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发表时间：
2001-11-01
影响因子：
4.9
通讯作者：
Duarte, AJS
中科院分区：
文献类型：
--
作者：
Brigido, LFM;Rodrigues, R;Duarte, AJS
这项研究的目的是评估一项简单的评估，即坚持抗逆转录病毒治疗，是否与临床和实验室结果相关。我们跟踪了一家公立教学医院艾滋病门诊的公开队列患者。根据依从性将患者分类为：规则(REG)，最佳，所有剂量全天，仅耐受不规则的服药时间(+/-2小时)；准规则(QREG)，一个月内错过四剂或一整天的患者；不规则(IRREG)，所有其他非规则方案，以及忽略(IGN)，没有信息的患者。将一份简单问卷的结果与CD4(+)细胞计数和人类免疫缺陷病毒1型(HIV-1)RNA血浆病毒血症进行比较。分析了182例HIV-1感染者(男性69%，女性56例，31%)。关于依从性的信息有168人(90%)。75例(41%)患者报告了REG依从性，35例(19%)患者报告了qREG依从性，53例(29%)患者报告了IRREG依从性。不坚持的主要原因是健忘、不耐受、饮酒和对处方的误解。仅在REG和qREG使用者中观察到CD4+T细胞计数和绝对增益显著增加(P
The objective of this study was to assess if a simple evaluation, adherence to antiretroviral therapy, would correlate to clinical and laboratory outcomes. We followed an open cohort of patients from a public teaching hospital AIDS outpatient clinic. Patients were categorized according to adherence as: regular (Reg), optimal, all doses all days, tolerating only irregular timing (+/-2 hours) of intake; quasi-regular (qReg), those missing up to four doses or 1 full day during a month; irregular (Irreg), all other irregular regimens, and ignored (Ign), those without information. The results from a simple questionnaire were compared to CD4(+) cell counts and human immunodeficiency virus type 1 (HIV-1) RNA plasma viremia. One hundred eighty-two HIV-1-infected patients (126 males, 69%; 56 females, 31%) were analyzed. Information on adherence was available for 168 (90%). Reg adherence was reported by 75 (41%) patients, qReg adherence by 35 (19%), and Irreg by 53 (29%) of patients. The main reasons for nonadherence were forgetfulness, intolerance, use of alcohol, and misunderstanding of prescription. A significant increase of CD4+ T-cell counts and absolute gain were only observed among Reg and qReg users (p