Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones
Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones
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DOI：
10.1111/j.1742-7843.2009.00455.x
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发表时间：
2009-11-01
影响因子：
3.1
通讯作者：
Sandborgh-Englund, Gunilla
中科院分区：
文献类型：
--
作者：
Allmyr, Mats;Panagiotidis, Georgios;Sandborgh-Englund, Gunilla
三氯生是一种抗菌化合物，通常用于化妆品和个人护理产品的日常使用。如前所述，三氯生存在于不同人群的血浆、尿液和牛奶中。最近的研究表明，三氯生能够在体外激活人妊娠X受体，从而可能通过诱导CYP3A4影响人体内药物的代谢。此外，三氯生已被证明影响大鼠体内甲状腺激素水平。在本研究中，我们调查了12名成年人连续14天每天通过含三氯生的牙膏接触三氯生是否会导致血浆4 β -羟胆固醇增加，这表明CYP3A4的诱导和/或甲状腺激素状态的改变。暴露后血浆三氯生浓度从0.009 ~ 0.81 ng/g增加到26 ~ 296 ng/g（范围）。尽管如此，暴露期间血浆4 β -羟胆固醇或甲状腺激素水平均未发生显著变化。这表明，正常使用含三氯生的牙膏不太可能通过诱导CYP3A4来改变药物的代谢，也不会因为人类甲状腺紊乱而引起不良事件。
Triclosan is an antibacterial compound commonly used in cosmetics and personal care products for everyday use. As previously shown, triclosan is found in the plasma, urine and milk from large parts of different human populations. Recent studies have revealed that triclosan is able to activate the human pregnane X receptor in vitro and thus possibly affecting metabolism of drugs in humans via the induction of CYP3A4. Besides, triclosan has been shown to affect thyroid hormonal levels in rats in vivo. In the present study, we investigated if an everyday exposure to triclosan via triclosan-containing toothpaste for 14 days in 12 adult humans caused an increase in plasma 4 beta-hydroxycholesterol, indicative of CYP3A4 induction, and/or alterations in thyroid hormonal status. The plasma triclosan concentrations increased from 0.009-0.81 ng/g to 26-296 ng/g (ranges) upon exposure. Despite this, there were no significant changes in plasma levels of either plasma 4 beta-hydroxycholesterol or thyroid hormones during the exposure. This indicates that the normal use of triclosan-containing toothpaste is not likely to alter metabolism of drugs via CYP3A4 induction or cause adverse events because of thyroid disturbances in humans.