The travels of mRNAs in neurons: do they know where they are going?
The travels of mRNAs in neurons: do they know where they are going?
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DOI：
10.1016/j.conb.2019.01.016
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发表时间：
2019-08-01
影响因子：
5.7
通讯作者：
Yoon, Young J.
中科院分区：
文献类型：
--
作者：
Das, Sulagna;Singer, Robert H.;Yoon, Young J.
神经元是高度极化的细胞，可以将突起延伸到远离细胞体的地方。因此，信使RNA的运输就像一套在远端合成特定蛋白质的蓝图。RNA定位于树突和轴突赋予了在空间和时间上以非凡的精度调节翻译的能力。尽管RNA定位的理论基础相当令人信服，但尚不清楚神经元如何协调将一千多个不同的nnRNA分配到各自的亚细胞室的复杂任务。最近的单分子成像研究使人们对单个mRNAs的动力学有了深入的了解。我们现在可以窥探mRNAs在树突和轴突中的运输动力学。
Neurons are highly polarized cells that can extend processes far from the cell body. As such, transport of messenger RNAs serves as a set of blueprints for the synthesis of specific proteins at distal sites. RNA localization to dendrites and axons confers the ability to regulate translation with extraordinary precision in space and time. Although the rationale for RNA localization is quite compelling, it is unclear how a neuron orchestrates such a complex task of distributing over a thousand different nnRNAs to their respective subcellular compartments. Recent single-molecule imaging studies have led to insights into the kinetics of individual mRNAs. We can now peer into the transport dynamics of mRNAs in both dendrites and axons.