Epidemiology of gastrointestinal and liver tumors.
Epidemiology of gastrointestinal and liver tumors.
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DOI：
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发表时间：
2010-04
影响因子：
3.3
通讯作者：
L. Herszényi;Z. Tulassay
中科院分区：
文献类型：
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作者：
L. Herszényi;Z. Tulassay
结直肠癌（CRC）是一个世界性难题，每年发病100万例，每年死亡50多万例。CRC是癌症死亡的第二大常见原因。CRC占全球癌症负担的9%，在北美，澳大利亚，新西兰和欧洲部分地区最常见，被认为是西方生活方式的疾病。尽管胃癌的发病率和死亡率大幅下降，但胃癌仍然是世界范围内的一个重要公共卫生负担，特别是在发展中国家。胃癌仍然是第四大常见癌症，也是第二至第三大常见癌症死亡原因。最高和最低风险人群之间的发病率差异为10倍。在东亚、东欧以及中美洲和南美洲的部分地区，发病率特别高。食管癌是全球第八大常见癌症，也是癌症相关死亡的第六大常见原因。南部和东部非洲以及中国的区域发病率最高。食管腺癌的发病率显著增加，相反，鳞状细胞癌的发病率呈稳定甚至下降趋势。胰腺癌在男性和女性中分别排名第四和第五位，并且在所有胃肠道肿瘤中具有最低的5年生存率。肝细胞癌（HCC）是世界上第六大常见癌症，也是第三大常见癌症死亡原因。
Colorectal cancer (CRC) is a worldwide problem, with an annual incidence of 1 million cases and an annual mortality of more than 500,000 cases. CRC is the second most common cause of cancer mortality. CRC comprises 9% of the global cancer burden and is the most frequent in North America, Australia, New Zealand and parts of Europe, being considered as a disease of the Western lifestyle. Despite a major decline in incidence and mortality, gastric cancer remains an important public health burden worldwide, especially in developing countries. Gastric cancer is still the fourth most common cancer and the second-third most common cause of cancer death. There is a 10-fold variation in incidence between populations at the highest and lowest risk. The incidence is particularly high in East Asia, Eastern Europe, and parts of Central and South America. Esophageal cancer is the eighth most common cancer worldwide and the sixth most common cause of cancer-related death. Regional incidence rates are highest in areas of Southern and Eastern Africa and China. A striking increase in the rates of esophageal adenocarcinoma, in contrast, stable or even decreased trends in squamous cell cancer have been observed. Pancreatic cancer ranks the fourth and fifth most common cancer in man and women, respectively, and has the lowest 5-year survival rate of any gastrointestinal tumors. Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third most common cause of cancer mortality.