Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation.
Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation.
复制标题
辐射诱导的小鼠胸腺淋巴瘤中 P16 DNA 甲基化增加
DOI：
10.1371/journal.pone.0093850
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sun S
中科院分区：
文献类型：
--
作者：
Song W;Liu Y;Liu Y;Zhang C;Yuan B;Zhang L;Sun S
DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples. The mRNA and protein levels of P16 were significantly reduced in radiation-induced thymic lymphoma tissue samples. Twenty-three CpG sites of the CpG islands in the p16 promoter region were detected, and the methylation percentages of −71, −63, −239, −29, −38, −40, −23, 46 CpG sites were significantly higher in radiation-induced thymic lymphoma tissue samples than those in matched non-irradiated thymus tissue samples. This study provides new evidence for the methylation state of p16 in the radiation-induced thymic lymphoma samples, which suggests that the methylation of these CpG sites in the p16 promoter may reduce its expression in the thymic lymphoma after irradiation.
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DOI：
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发表时间：
2003-02-05
影响因子：
1.9
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2004-04-14
影响因子：
2.3
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