Control of ameloblast differentiation.
Control of ameloblast differentiation.
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DOI：
10.1387/ijdb.7626423
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
M. Zeichner‐David;Thomas GH Diekwisch;A. Fincham;Eduardo C. Lau;M. Macdougall;Janet Moradian-oldak;J. P. Simmer;Malcolm L. Snead;Harold C. Slavkin
中科院分区：
文献类型：
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作者：
M. Zeichner‐David;Thomas GH Diekwisch;A. Fincham;Eduardo C. Lau;M. Macdougall;Janet Moradian-oldak;J. P. Simmer;Malcolm L. Snead;Harold C. Slavkin
这篇综述重点介绍了在理解从口腔外胚层起源的牙源性胎盘到矿化牙釉质细胞外基质形成的一系列事件的顺序发育级联过程方面的一些进展。综述了近年来发现的与上皮-间充质相互作用相关的生长因子、生长因子受体和转录因子，以及随后对成釉细胞分化的调控。对成釉细胞细胞学、终末分化与生化表型的关系进行了讨论。分析成釉细胞表型的组织特异性基因产物及其在釉质基质形成中的可能功能，以及成熟期成釉细胞在控制釉质生物矿化中的作用。最后，对成釉细胞或特定基因产物的改变导致异常釉质表型的病理条件进行了综述。显然，过去几年在涉及牙齿发育的分子决定因素方面取得的科学进展是显著的。然而，对于控制成釉细胞分化和釉质生物矿化的确切机制仍然缺乏相当大的了解。预期的进展仍然需要更多的国际合作和协作，以及更多地利用釉质细胞外基质蛋白的结构生物学研究。
This review highlights a number of advances towards understanding the sequential developmental cascade of events beginning in the oral ectodermally-derived odontogenic placode and culminating in the formation of the mineralized enamel extracellular matrix. Recent discoveries of growth factors, growth factor receptors and transcription factors associated with instructive epithelial-mesenchymal interactions and subsequent controls for ameloblast cell differentiation are reviewed. The relationship between ameloblast cytology, terminal differentiation and biochemical phenotype are discussed. The tissue-specific gene products characteristic of the ameloblast phenotype as well as their possible functions in formation of the enamel matrix are analyzed as well as the role of maturation-stage ameloblast cells in controlling enamel biomineralization. Finally, pathological conditions in which alterations in the ameloblast or specific gene products result in an abnormal enamel phenotype are reviewed. Clearly, the scientific progress achieved in the last few years concerning the molecular determinants involved in tooth development has been remarkable. However, there remains considerable lack of knowledge regarding the precise mechanisms that control ameloblast differentiation and enamel biomineralization. Anticipated progress continues to require increased international cooperation and collaborations as well as increased utilization of structural biology investigations of enamel extracellular matrix proteins.