Salivary cortisol patterns in vital exhaustion
Salivary cortisol patterns in vital exhaustion
复制标题
DOI：
10.1016/s0022-3999(00)00166-5
复制
发表时间：
2000-11-01
影响因子：
4.7
通讯作者：
van Diest, R
中科院分区：
文献类型：
--
作者：
Nicolson, NA;van Diest, R
目标：生命衰竭综合征（VE）是心肌梗死的危险指标，其特征是过度疲劳、易怒和士气低落。下丘脑-垂体-肾上腺皮质（HPA）轴的失调是疲劳综合征的一个潜在的致病机制，但对VE综合征中HPA的功能知之甚少。方法：我们评估了基础游离皮质醇水平和响应的语音任务，并通过收集多个唾液样本超过2天从29 VE男性和30个对照组的早晨醒来。结果：VE受试者比对照组报告更高的感知压力，更差的睡眠，更大的疲劳。VE受试者的基础皮质醇水平较低，特别是在晚上，与疲劳呈负相关。总的皮质醇对语音任务的反应在VE组和对照组中是相似的，尽管VE受试者不太可能表现出大的（大于或等于2.76 nmol/l）反应。皮质醇对觉醒的反应与同时发生的疲劳和睡眠质量差有关。结论：这些发现表明VE中存在轻微的HPA活动减退，这可能是由于慢性压力和相关的睡眠障碍引起的。(C)2000 Elsevier Science Inc. All rights reserved.
Objective: The syndrome of vital exhaustion (VE), a risk indicator for myocardial infarction, is characterized by excessive fatigue, irritability, and demoralization. Dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis is a potential pathogenic mechanism in fatigue syndromes, but little is known about HPA function in syndromal VE. Method: We assessed basal free cortisol levels and responses to a speech task and to morning awakening by collecting multiple saliva samples over 2 days from 29 VE men and 30 controls. Results: VE subjects reported higher perceived stress, poorer sleep, and greater fatigue than controls. Basal cortisol levels were lower in VE subjects, especially in the evening, and were negatively associated with fatigue. Overall cortisol responses to the speech task were similar in VE and control groups, although VE subjects were less likely to show large (greater than or equal to2.76 nmol/l) responses. The cortisol response to awakening was associated with concurrent fatigue and poor sleep quality. Conclusion: These findings suggest a subtle HPA hypoactivity in VE, which may arise through chronic stress and associated sleep disturbances. (C) 2000 Elsevier Science Inc. All rights reserved.