Advanced structural multimodal imaging of a patient with subcortical band heterotopia.
Advanced structural multimodal imaging of a patient with subcortical band heterotopia.
复制标题
皮质下带状异位患者的高级结构多模态成像。
DOI：
10.1002/epi4.12019
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发表时间：
2016
期刊：
影响因子：
3
通讯作者：
Davis,KathrynA
中科院分区：
文献类型：
--
作者：
Kini,LohithG;Nasrallah,IlyaM;Coto,Carlos;Ferraro,LindsayC;Davis,KathrynA
皮质下带状异位(SBH)是一种神经元迁移障碍，最常见的原因是双皮质素(DCX)基因突变。可以看到一系列的表型，大多数患者都有一定程度的癫痫和智力残疾。先进的扩散和结构磁共振成像(MRI)序列可能有助于在耐药癫痫中识别不同大小的异位和异型。我们描述了一位患有SBH和耐药癫痫的患者，并通过使用多种先进的MRI方式，与健康对照组比较，研究了轴突密度、轴突弥散和扩散参数。异位症的轴突密度和分布更接近于白质而不是灰质。使用弥散成像获得的轴突密度和弥散度图可能能够更好地描述不同亚型的异位。
Subcortical band heterotopia (SBH) is a disorder of neuronal migration most commonly due to mutations of theDoublecortin(DCX) gene. A range of phenotypes is seen, with most patients having some degree of epilepsy and intellectual disability. Advanced diffusion and structural magnetic resonance imaging (MRI) sequences may be useful in identifying heterotopias and dysplasias of different sizes in drug‐resistant epilepsy. We describe a patient with SBH and drug‐resistant epilepsy and investigate neurite density, neurite dispersion, and diffusion parameters as compared to a healthy control through the use of multiple advanced MRI modalities. Neurite density and dispersion in heterotopia was found to be more similar to white matter than to gray matter. Neurite density and dispersion maps obtained using diffusion imaging may be able to better characterize different subtypes of heterotopia.