CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain
CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain
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DOI：
10.1016/s1074-7613(01)00240-0
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发表时间：
2001-12-01
期刊：
影响因子：
32.4
通讯作者：
Bendelac, A
中科院分区：
文献类型：
--
作者：
Jayawardena-Wolf, J;Benlagha, K;Bendelac, A
内体运输是脂质抗原呈递给T细胞的CD 1途径的重要组成部分。我们表明，CD1d进入内体室是在双重调节下的内在酪氨酸基序，它管理强烈的质膜和内体之间的再循环，并通过不变的链，其中CD1d协会在内质网。这两种途径独立地增强抗原呈递给V α 14（+）NKT细胞，CD1d限制性T细胞的主要亚群。这些结果揭示了CD1d运输的复杂性，并表明在MHC和CD1进化之前，不变链是祖先抗原呈递途径的一个组成部分。
Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d associates in the endoplasmic reticulum. Both pathways independently enhance antigen presentation to V alpha 14(+) NKT cells, the main subset of CD1d-restricted T cells. These results reveal the complexity of CD1d trafficking and suggest that the invariant chain was a component of ancestral antigen presentation pathways prior to the evolution of MHC and CD1.