EVIDENCE THAT TRANSCRIPTION OF THE HEXOKINASE GENE IS INCREASED IN A RAPIDLY GROWING-RAT HEPATOMA
EVIDENCE THAT TRANSCRIPTION OF THE HEXOKINASE GENE IS INCREASED IN A RAPIDLY GROWING-RAT HEPATOMA
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DOI：
10.1016/0006-291x(85)90948-9
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发表时间：
1985-01-01
影响因子：
3.1
通讯作者：
NELSON, BD
中科院分区：
文献类型：
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作者：
JOHANSSON, T;BERREZ, JM;NELSON, BD
大鼠肝脏和大鼠腹水型肝癌（Zajdela）中己糖激酶特异性mRNA的水平通过在网状细胞裂解液中翻译两种细胞类型的游离多体来评估。肿瘤细胞中己糖激酶的翻译频率大约是肝脏的10倍，这表明转录激活是肿瘤中己糖激酶水平升高的部分原因。
The level of hexokinase-specific mRNA in rat liver and in rat ascites hepatoma (Zajdela) was assessed by translating free polysomes from both cell types in a reticulocyte lysate. Translation of hexokinase occurred with approximately a 10 fold higher frequency in tumor cells than in liver, suggesting that transcriptional activation is in part responsible for increased levels of hexokinase in tumor.