Claudin-1 expression in cervical cancer
Claudin-1 expression in cervical cancer
复制标题
DOI：
10.3892/mco.2017.1391
复制
发表时间：
2017-11-01
影响因子：
1.2
通讯作者：
Hanker, Lars
中科院分区：
文献类型：
--
作者：
Hoellen, Friederike;Waldmann, Annika;Hanker, Lars
Claudin-1是一种紧密连接蛋白，已被证明参与多种类型实体瘤的肿瘤发生和肿瘤进展。本研究采用免疫组化方法分析了106例宫颈鳞癌组织中daudin-1蛋白的表达。此外，我们还分析了claudin-1表达的等级与某些临床病理参数的关系。与瘤周间质相比，claudin-1在肿瘤细胞中明显过表达。claudin-1表达与FIGO分期、肿瘤大小、分级或远处转移灶的出现无显著相关性。与claudin-1阴性患者（7.1%）相比，claudin-1蛋白表达阳性的宫颈癌患者更容易出现淋巴结转移（28.3%）。关于总生存期，本研究结果表明，claudin-1阴性患者预后较好。为了阐明claudin-1过表达是否对宫颈鳞状癌的预后有显著影响，还需要进一步的研究。
Claudin-1 is a tight junction protein that has been demonstrated to be involved in tumorigenesis and tumor progression in various types of solid tumors. In the present study, the protein expression of daudin-1 in squamous cervical cancer tissues obtained from 106 patients was analyzed by immunohistochemistry. In addition, the grade of claudin-1 expression was analyzed for associations with certain clinicopathological parameters. A significant overexpression of claudin-1 was detected in the tumor cells, when compared with that in the peritumoral stroma. There was no significant association between claudin-1 expression and FIGO stage, tumor size, grading or the appearance of distant metastases. Cervical cancer patients scoring positive for claudin-1 protein expression tended to exhibit more lymph node metastasis (28.3%), compared with claudin-1-negative patients (7.1%). Regarding overall survival, the results of the present study suggest a better prognosis for claudin-1-negative patients. In order to elucidate whether claudin-1 overexpression has a significant prognostic impact on squamous cervical cancer, further studies arc required.