Relationship between Campylobacter pylori and gastritis in healthy humans after administration of placebo or indomethacin.
Relationship between Campylobacter pylori and gastritis in healthy humans after administration of placebo or indomethacin.
复制标题
健康人服用安慰剂或吲哚美辛后幽门弯曲菌与胃炎的关系。
DOI：
10.1016/0016-5085(88)90349-6
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Feldman,M
中科院分区：
文献类型：
--
作者：
Peterson,WL;Lee,E;Feldman,M
在23名健康志愿者中，内镜和显微镜下胃窦和基底粘膜的外观与幽门弯曲杆菌的存在或不存在以及与该生物的血浆免疫球蛋白G抗体相关，其中12人接受了吲哚美辛治疗，11人未接受任何药物治疗。AntralC。23例活检标本中有9例（对照组11例中有3例，消炎痛组12例中有6例，差异无统计学意义）发现幽门螺杆菌与活动性浅表胃窦炎的组织学证据密切相关（p < 0.005），但与胃窦的内镜外观无关。与上颌窦不同的是，基底部。23个活检标本中有14个（61%）发现幽门螺杆菌，常与组织学和内镜下正常的眼底黏膜相关。幽门弯曲杆菌相关的活动性胃炎仅发生在眼底有这种细菌的受试者中。血浆免疫球蛋白G抗体滴度。幽门螺杆菌相关胃炎患者幽门螺杆菌感染率最高，未感染幽门螺杆菌的患者幽门螺杆菌感染率最低。这些研究表明，健康的人可能携带。幽门螺杆菌在近端胃无明显不良反应。在其中一些个体中，这种微生物也累及胃窦，并与活动性胃炎有关。
Endoscopic and microscopic appearances of antral and fundic mucosa were correlated with the presence or absence ofCampylobacter pylori—and with plasma immunoglobulin G antibodies to that organism—in 23 healthy volunteers, 12 of whom had received indomethacin and 11 of whom had received no medication. AntralC. pylori, found in 9 of 23 biopsy specimens (3 of 11 controls, 6 of 12 indomethacin-treated patients; not significantly different), correlated strongly with histologic evidence of active superficial antral gastritis (p < 0.005), but not with the endoscopic appearance of the antrum. In contrast to the antrum, fundicC. pylori, found in 14 of 23 biopsy specimens (61%), were frequently associated with histologically and endoscopically normal fundic mucosa.Campylobacter pylori-associated active antral gastritis occurred only in subjects whose fundus harbored this organism. Plasma immunoglobulin G antibody titers toC. pyloriwere highest in subjects withCampylobacter-associated antral gastritis and lowest in subjects without gastricCampylobacter. These studies suggest that healthy humans may harborC. pyloriin their proximal stomach without apparent ill effects. In some of these individuals, the organism also involves the antrum and is associated with active gastritis.