Comparison of ankle-brachial pressure index and pulse wave velocity as markers of the presence of coronary artery disease in subjects with a high risk of atherosclerotic cardiovascular disease
Comparison of ankle-brachial pressure index and pulse wave velocity as markers of the presence of coronary artery disease in subjects with a high risk of atherosclerotic cardiovascular disease
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DOI：
10.1016/j.amjcard.2004.06.020
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发表时间：
2004-10-01
影响因子：
2.8
通讯作者：
Yamashina, A
中科院分区：
文献类型：
--
作者：
Koji, Y;Tomiyama, H;Yamashina, A
近年来，可以同时测量踝臂压力指数（ABI）和臂踝脉搏波速度（PWV）的测量装置已经变得可用。本研究比较了ABI和PWV作为预测冠状动脉疾病（CAD）患病率的指标在动脉粥样硬化性心血管疾病高危人群中的适用性。在472名连续受试者中测量ABI和臂踝PWV，这些受试者随后接受冠状动脉造影以诊断或排除CAD。ABI最低四分位数的CAD患病率高于其他3个ABI四分位数，而臂踝PWV最低四分位数的CAD患病率低于其他3个臂踝PWV四分位数。多变量Logistic回归分析表明，最低ABI四分位数是一个显着的独立变量的患病率CAD和最低臂踝PWV四分位数是一个显着的独立变量的情况下，CAD的人口。因此，在动脉粥样硬化性心血管疾病高风险受试者中，低ABI是CAD附加风险的独立标志物，而低臂踝PWV可用作排除CAD风险的独立标志物。(C)2004年，Excerpta Medica，Inc.
Recently, a measurement device that can simultaneously measure the ankle-brachial pressure index (ABI) and brachial-ankle pulse wave velocity (PWV) has become available. The present study compares the applicability of ABI and PWV as markers for predicting the prevalence of coronary artery disease (CAD) in subjects with a high risk of atherosclerotic cardiovascular disease. The ABI and brachial-ankle PWV were measured in 472 consecutive subjects who subsequently underwent coronary angiography for diagnosis or exclusion of CAD. The prevalence of CAD in the lowest ABI quartile was higher than those in the other 3 ABI quartiles, whereas the prevalence in the lowest brachial-ankle PWV quartile was lower than those in the other 3 brachial-ankle PWV quartiles. A multivariate logistic regression analysis demonstrated that the lowest ABI quartile was a significant independent variable for the prevalence of CAD and that the lowest brachial-ankle PWV quartile was a significant independent variable for the absence of CAD in a population. Thus, a low ABI is an independent marker for an additive risk of CAD, whereas a low brachial-ankle PWV may be used as an independent marker for excluding the risk of CAD among subjects with a high risk of atherosclerotic cardiovascular disease. (C) 2004 by Excerpta Medica, Inc.