Correlation of sex hormone and androgen receptor with diabetes mellitus in elderly men
Correlation of sex hormone and androgen receptor with diabetes mellitus in elderly men
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DOI：
10.3109/13685538.2011.575479
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发表时间：
2011-08
期刊：
影响因子：
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通讯作者：
Jian Cao;Jian Li;Wei-jun Hao;Xiaoying Li;Hao Wang;Lin Liu;Bing-po Zhu;Zhiqin Guo
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文献类型：
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作者：
Jian Cao;Jian Li;Wei-jun Hao;Xiaoying Li;Hao Wang;Lin Liu;Bing-po Zhu;Zhiqin Guo
目的。研究老年男性的性激素和雄激素受体（AR）水平并评估其与糖尿病（DM）的关系。方法。这项横断面研究包括 492 名老年男性，其中包括 104 名健康受试者（平均年龄 71.4 ± 5.2 岁）、259 名无糖尿病受试者（71.5 ± 5.0 岁）和 129 名糖尿病患者（73.0 ± 6.3 岁）。测定总睾酮（TT）、游离睾酮（FT）、硫酸脱氢表雄酮、性激素结合球蛋白（SHBG）、雌二醇（E2）、黄体生成素和卵泡刺激素（FSH）的血浆浓度。 AR阳性细胞通过流式细胞术测量。结果。 DM 组的 TT 浓度 (13.8 ± 4.7 nmol/l) 显着低于健康组 (17.1 ± 6.1 nmol/l) 和非糖尿病组 (15.8 ± 6.0 nmol/l；所有 P < 0.01)。健康组、非糖尿病组和糖尿病组中FT、SHBG、AR阳性比例（AR%）和AR荧光强度均呈下降趋势，但差异不显着。 TT、E2、E2/睾酮和SHBG与血糖呈负相关。 SHBG与DM病程呈正相关，TT和AR%与DM病程呈负相关。 Logistic多元回归分析显示，年龄、腰臀比、FSH、SHBG和AR%是DM的潜在危险因素。结论。低水平的 TT、SHBG 和 AR 可能是老年男性患 DM 的潜在危险因素。
Aim. To investigate sex hormone and androgen receptor (AR) levels and to evaluate their relationship with diabetes mellitus (DM) in senile men. Methods. The cross-sectional study included 492 elderly men comprising 104 healthy subjects (mean age 71.4 ± 5.2 years), 259 subjects without DM (71.5 ± 5.0 years) and 129 DM patients (73.0 ± 6.3 years). Plasma concentrations of total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulphate, sex hormone-binding globulin (SHBG), estradiol (E2), luteinising hormone) and follicle-stimulating hormone (FSH) were determined. AR-positive cells were measured by flow cytometry. Results. TT concentrations were significantly lower in the DM group (13.8 ± 4.7 nmol/l) than in the healthy (17.1 ± 6.1 nmol/l) and non-diabetes groups (15.8 ± 6.0 nmol/l; all P < 0.01). FT, SHBG, AR-positive proportion (AR%) and AR fluorescence intensity showed a decreasing trend among the healthy, non-DM and DM groups, but the differences were not significant. TT, E2, E2/testosterone and SHBG were negatively correlated with blood glucose. SHBG was positively correlated and TT and AR% were negatively correlated with the course of DM. Logistic multiple regression analysis revealed that age, waist/hip ratio, FSH, SHBG and AR% are potential risk factors for DM. Conclusions. Low levels of TT, SHBG and AR may be potential risk factors for DM in elderly men.