Survivin expression in ovarian carcinoma: Correlation with apoptotic markers and prognosis
Survivin expression in ovarian carcinoma: Correlation with apoptotic markers and prognosis
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DOI：
10.1097/01.mp.0000073868.31297.b0
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发表时间：
2003-06-01
期刊：
影响因子：
7.5
通讯作者：
Santoianni, R
中科院分区：
文献类型：
--
作者：
Cohen, C;Lohmann, CM;Santoianni, R
存活素是一种新的细胞凋亡抑制剂，通常在胎儿发育期间的组织和癌症中检测到，但通常不在正常组织中。这种蛋白质的表达在许多癌症中可能具有预后意义和治疗相关性。我们评估了卵巢癌中生存素的表达，将结果与其他抗凋亡（bcl-2，bcl-x，突变型p53）和促凋亡（bax）标记物的表达，预后参数和预后相关。49例卵巢癌的石蜡包埋切片进行了survivin、bcl-2、bcl-x、bax和p53的免疫染色。以强度（0-3+）评价细胞核和细胞质中的表达，并在四层系统上对阳性细胞的百分比进行评分，
Survivin is a novel inhibitor of apoptosis commonly detected in tissues during fetal development and in cancer, but not usually in normal tissues. Expression of this protein may be of prognostic significance and therapeutically relevant in many cancers. We assessed survivin expression in ovarian carcinoma, correlating results with expression of other anti-apoptotic (bcl-2, bcl-x, mutant p53) and proapoptotic (bax) markers, with prognostic parameters, and prognosis. Paraffin-embedded sections of 49 ovarian carcinoma were immunostained for survivin, bcl-2, bcl-x, bax, and p53. Expression was evaluated in nuclei and cytoplasm, as intensity (0-3+), and percentage of positive cells was scored on a four-tiered system with