Energy substrate metabolism among habitually violent alcoholic offenders having antisocial personality disorder.
Energy substrate metabolism among habitually violent alcoholic offenders having antisocial personality disorder.
复制标题
患有反社会人格障碍的习惯性暴力酗酒者的能量底物代谢。
DOI：
10.1016/j.psychres.2006.01.013
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发表时间：
2007
影响因子：
11.3
通讯作者：
Tiihonen,Jari
中科院分区：
文献类型：
--
作者：
Virkkunen,Matti;Rissanen,Aila;Naukkarinen,Hannu;Franssila-Kallunki,Anja;Linnoila,Markku;Tiihonen,Jari
西方国家的暴力犯罪很大一部分可归因于反社会人格障碍（APD）。多项研究表明，患有 APD 的习惯性暴力酗酒者的脂质、碳水化合物和脑脊液 (CSF) 单胺代谢物水平较低，但尚不清楚这些生化异常在这种疾病中如何相互关联。我们的目的是研究患有 APD 的习惯性暴力罪犯的能量底物代谢。对 96 名习惯性暴力反社会男性酗酒者和 40 名正常男性对照进行胰岛素敏感性（正常血糖胰岛素钳夹）、基础能量消耗（间接量热法）和脑脊液 5-羟基吲哚乙酸 (5-HIAA) 测量。与正常对照组相比，习惯性暴力、患有 APD 的监禁罪犯的非氧化葡萄糖代谢、基础胰高血糖素和游离脂肪酸显着较低，但葡萄糖氧化和 CSF 5-HIAA 在这些组之间没有显着差异。与对照组相比，监禁和非监禁 APD 受试者中非氧化葡萄糖代谢较低的效应大小分别为 0.73 和 0.51，表明这一发现不能用监禁来解释。与健康对照组相比，患有 APD 的习惯性暴力犯罪者的胰高血糖素和非氧化葡萄糖代谢明显较低，这些发现与习惯性暴力犯罪的相关性高于低 CSF 5-HIAA 水平，而 CSF 5-HIAA 水平是冲动暴力行为的公认标志。需要进行后续研究来确认是否可以利用异常的葡萄糖和脂质代谢来预测 APD 罪犯一生中的暴力犯罪行为。
A large proportion of violent offences in Western countries are attributable to antisocial personality disorder (APD). Several studies have shown abnormal lipid, carbohydrate and low cerebrospinal fluid (CSF) monoamine metabolite levels in habitually violent alcoholic offenders with APD, but it is not clear how these biochemical abnormalities are related to each other in this disorder. We aimed to study energy substrate metabolism among habitually violent offenders with APD. Insulin sensitivity (euglycemic insulin clamp), basal energy expenditure (indirect calorimetry), and CSF 5-hydroxyindoleacetic acid (5-HIAA) measurements were performed on 96 habitually violent antisocial male alcoholic offenders and on 40 normal male controls. Habitually violent, incarcerated offenders with APD had significantly lower non-oxidative glucose metabolism, basal glucagon, and free fatty acids when compared with normal controls, but glucose oxidation and CSF 5-HIAA did not differ markedly between these groups. The effect sizes for lower non-oxidative glucose metabolism among incarcerated and non-incarcerated APD subjects were 0.73 and 0.51, respectively, when compared with controls, indicating that this finding was not explained by incarceration. Habitually violent offenders with APD have markedly lower glucagon and non-oxidative glucose metabolism when compared with healthy controls, and these findings were more strongly associated with habitual violent offending than low CSF 5-HIAA levels, a well-established marker for impulsive violent behavior. Follow-up studies are needed to confirm if abnormal glucose and lipid metabolism can be used to predict violent offending over the course of the APD offender's life span.