Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.
Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.
复制标题
合成脱氢丙氨酸片段作为硫链丝菌素侧链模拟物。
DOI：
10.1016/j.bmcl.2005.03.084
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Hermann,Thomas
中科院分区：
文献类型：
--
作者：
Ayida,BenjaminK;Simonsen,KlausB;Vourloumis,Dionisios;Hermann,Thomas
脱氢丙氨酸衍生物的合成通过固相支持路线，从硒代半胱氨酸开始，并通过常规的溶液相化学描述沿着与初始的生物测试。目标化合物被设计为作用于细菌核糖体的大环抗生素硫链丝菌素的脱氢丙氨酸侧链的模拟物。
Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.