Control of Nuclear Size by NPC Proteins
Control of Nuclear Size by NPC Proteins
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DOI：
10.1007/978-1-4899-8032-8_26
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发表时间：
2014-01-01
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影响因子：
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通讯作者：
Imamoto, Naoko
中科院分区：
文献类型：
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作者：
Takagi, Masatoshi;Imamoto, Naoko
癌细胞的细胞核结构经常以与肿瘤类型和侵袭性相关的方式改变。因此，它已成为肿瘤病理诊断和预后的中心标准。然而，这些观察到的核形态变化（包括大小）背后的分子机制仍然完全未知。基于我们目前对核孔复合物（NPC）及其成分（统称为核孔蛋白（Nups））的生理学的理解，我们讨论了NPC和核孔蛋白的结构和功能的消融如何直接或间接地促进了癌细胞中观察到的核大小的变化。
The architecture of the cell nucleus in cancer cells is often altered in a manner associated with the tumor type and aggressiveness. Therefore, it has been the central criterion in the pathological diagnosis and prognosis of cancer. However, the molecular mechanism behind these observed changes in nuclear morphology, including size, remains completely unknown. Based on our current understanding of the physiology of the nuclear pore complex (NPC) and its constituents, which are collectively referred to as nucleoporins (Nups), we discuss how the structural and functional ablation of the NPC and Nups could directly or indirectly contribute to the changes in nuclear size observed in cancer cells.