C1q and anti-C1q antibody levels are correlated with disease severity in Chinese pediatric systemic lupus erythematosus
C1q and anti-C1q antibody levels are correlated with disease severity in Chinese pediatric systemic lupus erythematosus
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DOI：
10.1007/s00296-009-1257-0
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发表时间：
2011-04-01
影响因子：
4
通讯作者：
Zhang, Wei
中科院分区：
文献类型：
--
作者：
Wu, Feng Qi;Zhao, Qing;Zhang, Wei
本研究旨在检测系统性红斑狼疮（PSLE）患儿血清补体lq（Clq）和抗C1 q抗体（ClqAb）水平，并分析其与疾病活动性及肾脏损害的相关性。我们调查了90例PSLE患者，其中活动期43例，缓解期47例。结果表明，PSLE患儿血清Clq水平明显低于健康儿童及其他风湿性疾病患儿。而PSLE患者的ClqAb水平显著高于其他组。血清Clq水平与系统性红斑狼疮（SLE）疾病活动指数（SLEDAI）呈负相关，ClqAb水平与SLEDAI及肾损害呈正相关。ClqAb诊断PSLE的敏感性为95.6%，特异性为97.5%。93.0% C1 qAb高水平的SLE患者同时存在肾脏损害。因此，血清C1 q和C1 qAb水平反映了SLE的病情严重程度。C1 q降低和C1 qAb升高与儿童狼疮性肾炎（LN）密切相关，对LN的诊断有一定价值。
The aim of this study was to measure the level of serum complement lq(Clq) and anti-C1q antibodies (ClqAb) in pediatric systemic lupus erythematosus (PSLE), and then analyze the correlation between the levels of serum Clq and ClqAb with disease activity and kidney damage. We investigated 90 PSLE patients, including 43 patients in active stage and 47 patients in remission. Our results showed that the level of serum Clq of PSLE patients was significantly lower than the level of healthy children and children with other rheumatic diseases. In contrast, the level of ClqAb of PSLE patients was significantly higher than the other groups. The level of serum Clq was negatively correlated with systemic lupus erythematosus (SLE) disease active index (SLEDAI) and the level of ClqAb was positively correlated with SLEDAI and kidney damage. The sensitivity of using ClqAb levels to diagnose PSLE was 95.6% and the specificity was 97.5%. 93.0% SLE patients who had high C1qAb levels also showed kidney damage. Therefore, the levels of C1q and C1qAb in serum reflect the disease severity of SLE. Decreased Clq and increased C1qAb is closely correlated with lupus nephritis (LN) in children and may have diagnosis values for child LN.