Nasopharyngeal carcinoma in Malaysian Chinese: occupational exposures to particles, formaldehyde and heat
Nasopharyngeal carcinoma in Malaysian Chinese: occupational exposures to particles, formaldehyde and heat
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DOI：
10.1093/ije/29.6.991
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发表时间：
2000-12-01
影响因子：
7.7
通讯作者：
Sani, S
中科院分区：
文献类型：
--
作者：
Armstrong, RW;Imrey, PB;Sani, S
背景1990-1992年，对马来西亚雪兰莪州和联邦直辖区282名经组织学证实患有鼻咽癌（NPC）的华人居民进行了职业史、饮食、饮酒和吸烟等方面的访谈，并对同等数量的马来西亚华人对照组进行了年龄和性别配对。结果鼻咽癌与职业暴露于建筑、金属和木材粉尘、发动机燃料和油、油漆和清漆、某些其他化学品、工业热、户外职业的太阳热、某些烟雾、吸烟和儿童暴露于父母吸烟有关。在调整饮食和吸烟的风险后，只有木尘（OR = 2.36; 95%CI：1.33-4.19）和工业热（OR = 2.21; 95%CI：1.12-4.33）仍然明显相关。在进一步调整社会阶层后，木尘仍然具有统计学意义。鼻咽癌与甲醛的关系未发现明显的粗关联或校正关联（校正OR = 0.71，95%CI：0.34-1.43）。结论本研究支持了以往的研究结果，即某些职业性吸入剂是鼻咽癌的危险因素。在调整饮食、吸烟和社会阶层后，木尘的统计效果仍然很大。强烈的工业高温是一个以前未报告的危险因素，即使在调整饮食和吸烟后也具有统计学意义。鼻咽癌与甲醛无相关性。
Background During 1990-1992, 282 Chinese residents of Selangor and the Federal Territory, Malaysia with histologically confirmed nasopharyngeal carcinoma (NPC) were interviewed about occupational history, diet, alcohol consumption, and tobacco use, as were an equal number of Malaysian Chinese population controls, pair-matched to cases by age and sex.Methods Exposures to 20 kinds of workplace substances, solar and industrial heat, and cigarette smoke, were analysed by univariate and multivariate methods.Results Nasopharyngeal carcinoma was associated with occupational exposures to construction, metal and wood dusts; motor fuel and oil; paints and varnishes: certain other chemicals; industrial heat; solar heat from outdoor occupations; certain smokes; cigarette smoking; and childhood exposure to parental smoking. After adjustment for risk from diet and cigarette smoke, only wood dust (OR = 2.36; 95% CI : 1.33-4.19), and industrial heat (OR = 2.21; 95% CI : 1.12-4.33) remained clearly associated. Wood dust remained statistically significant after further adjustment for social class. No significant crude or adjusted association was found between NPC and formaldehyde (adjusted OR = 0.71; 95% CI:0.34-1.43).Conclusions This study supports previous findings that some occupational inhalants are risk factors for NPC. The statistical effect of wood dust remained substantial after adjustment for diet, cigarette smoke, and social class. Intense industrial heat emerged as a previously unreported risk factor, statistically significant even after adjustment for diet and cigarette smoke. No association was found between NPC and formaldehyde.