GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1.
GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1.
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发表时间：
2000-11
期刊：
影响因子：
3.3
通讯作者：
C. Payne;Fan Zhang;A. Lloyd
中科院分区：
文献类型：
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作者：
C. Payne;Fan Zhang;A. Lloyd
拟南芥的毛状体发育和分化是植物细胞命运决定和形态发生的一个被广泛研究的模型。透明种皮GLABRA1(TTG1)的突变导致了几个多效性缺陷，包括几乎完全缺乏毛状体。Ttg1突变导致的复杂表型被玉米花青素调节基因R的异位表达抑制。本文证明拟南芥毛状体发育基因GLABRA3(GL3)编码一个R同源基因。GL3和GLABRA1(GL1)在植物中过表达时相互作用。酵母双杂交分析表明，GL3参与与GL1、TTG1及其自身的物理相互作用，但GL1和TTG1不相互作用。这些数据表明了一个重复的组合模型，用于不同发育途径的不同调控，如毛状体细胞命运决定、根毛间距和花青素次生代谢。
Arabidopsis trichome development and differentiation is a well-studied model for plant cell-fate determination and morphogenesis. Mutations in TRANSPARENT TESTA GLABRA1 (TTG1) result in several pleiotropic defects including an almost complete lack of trichomes. The complex phenotype caused by ttg1 mutations is suppressed by ectopic expression of the maize anthocyanin regulator R. Here it is demonstrated that the Arabidopsis trichome development locus GLABRA3 (GL3) encodes an R homolog. GL3 and GLABRA1 (GL1) interact when overexpressed together in plants. Yeast two-hybrid assays indicate that GL3 participates in physical interactions with GL1, TTG1, and itself, but that GL1 and TTG1 do not interact. These data suggest a reiterated combinatorial model for the differential regulation of such diverse developmental pathways as trichome cell-fate determination, root hair spacing, and anthocyanin secondary metabolism.